MKLN1 within the CTLH E3 ligase recognizes diverse substrates through multimodal engagement of acetylated, Arg, and C-degrons, revealing a versatile recognition mechanism.
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Ubiquitin and proteasome pathways
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Bruce inhibits wing tissue growth in Drosophila by regulating autophagy-dependent activation of non-lethal caspase Dcp-1.
- Open access
MKLN1 within the CTLH E3 ligase recognizes diverse substrates through multimodal engagement of acetylated, Arg, and C-degrons, revealing a versatile recognition mechanism.
- Open access
- 1 cites
Identification of three RING-type E3 ligases, including SGD1, linked to flowering-time variation and yield traits in Setaria italica.
Ubiquitin-dependent fate control and isoform diversity safeguard ZUP1, a key ubiquitin chain-editing enzyme, maintaining RPA turnover on ssDNA in cells.
- Open access
USP9X is essential for degrading ubiquitinated eRF1 on collided ribosomes by trimming K6-linked ubiquitin chains in quality control pathways.
- Open access
Mapping the dark proteome in cancer reveals thousands of previously uncharacterized proteins with potential roles in cancer biology and therapy.
Notch activation silences Hedgehog signaling via an E2-E3-E3 ubiquitin ligase module to specify germline stem cell niche in Drosophila ovary.
- Open access
CMA regulates a broad range of physiological functions and its dysfunction in ageing and disease causes cellular changes beyond damaged protein accumulation.
CLEO4-88 acts as a molecular glue with an EC50 of 12.5 nM to inhibit ACAA1 thiolase activity by inducing binding to GID4 in vitro and in cellulo.
- 1 cites
p97-mediated proteostasis is essential for late-stage thymocyte positive selection, with its loss causing a severe block in CD8+ lineage development in mice.
ABTB1 functions as an E3 ubiquitin ligase that promotes STAT3 degradation, suppressing Th17 cell differentiation and reducing autoimmune inflammation.
HSP70 depletion in HeLa cells causes over 90% reduction in transcript and protein levels, leading to a 1.8-fold increase in misfolded/aggregated proteins.
- Open access
A novel Pseudomonas aeruginosa E3 ligase, PUL-1, was identified and shown to regulate virulence in an animal infection model.
- Open access
HUWE1-HAPSTR1-USP7 complex amplifies ubiquitin chains on nuclear proteins, regulating stress-responsive degradation with a key role in neurodevelopmental disorders and cancer.
Kid (KIF22) forms a homodimer, moves processively along microtubules, and transports double-stranded DNA, challenging previous views of it as a monomeric, nonprocessive motor.
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Topics moving, week to 23 Oct 2026
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