Nature Chemical Biology
Nature Portfolio · Cell & Molecular Biology · ISSN 1552-4450, 1552-4469
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Latest in Nat Chem Biol
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Tryptoline acrylamide stereoprobes can disrupt the GRPEL1-HSPA9 complex by targeting nonorthosteric sites, impairing mitochondrial protein import and mitophagy.
- Open access
- 1 cites
SauUSI restriction enzyme motors fragment methylated DNA through ATP-driven translocation and looping, ultimately generating DNA fragments with blunt or 1-nt 3' overhangs.
A selective NVL inhibitor, MM927, suppresses tumor growth in vivo by disrupting ribosome biogenesis without toxicity.
PUS7-mediated pseudouridylation of 7SK enhances human somatic cell reprogramming efficiency and chromatin accessibility.
- Open access
- 1 cites
Proteome-guided drug discovery identified linker modifications that reduce hepatotoxicity and improve safety of androgen receptor-targeting degraders for prostate cancer.
- Open access
High-resolution NMR spectroscopy can be used to observe proteins within intact mitochondria, revealing detailed molecular interactions and stability at atomic resolution.
DHODH inhibition, not KDM4 suppression, underpins the antiproliferative effects of QC6352 and zavondemstat in glioblastoma models, with DHODH as the key target.
K27-linked ubiquitination of METTL14 by RLIM during the cell cycle regulates mRNA m6A levels independently of protein stability.
Pol II remodels cisplatin-induced interstrand crosslinks into a novel conformation that stalls transcription, with eight sequential states captured by cryo-EM.
Metagenomic enzymes targeting stable bonds in plastics show promise but currently lack sufficient activity for efficient nylon and polyurethane depolymerization.
Disruption of ROS rhythm through dual inhibition of IDO1 and AhR significantly prolongs survival in NSG mice with tumors.
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Topics moving, week to 23 Oct 2026
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