Tau regulates mitochondrial reverse electron transport, producing excess reactive oxygen species and driving neurodegeneration in tauopathies.
- 1 cited this week
Alzheimer's disease research and treatments
Moving in Neuron.
- Moved, week to 23 Oct 2026
- 3
- Papers in 60 days
- 87
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Hepatic expression of APOE3 Christchurch reduces amyloid-β burden and AD pathologies in APOE4-expressing APP/PS1 mice.
- 1 cites
Latest in Alzheimer's disease research and treatments
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Group II p21-activated kinases (PAKs) are identified as regulators of regional vulnerability to α-synuclein pathology in Parkinson's disease models.
- Open access
- 5 cites
Microglia in human forebrain organoids mediate amyloid-β clearance, recruit CD8+ T cells via CCL4/5 signaling, and establish a neuroinflammatory feedback loop in Alzheimer’s disease models.
- Open access
A non-canonical reactive astrocyte state (Ast10) is linked to neuropathologies and cognitive decline in Alzheimer's disease across diverse human brains.
- Open access
- 14 cites
Reducing ataxin-2 activates stress-adaptive metabolic pathways in neurons and astrocytes, providing broad protection against TDP-43 toxicity in ALS models.
- Open access
Amyloid clearance after aducanumab treatment is linked to reduced tau pathology and slower cortical atrophy in Alzheimer disease.
- Open access
Cytoplasmic TDP-43 gain-of-function causes splicing abnormalities linked to ALS, FTLD, and AD, including APP isoform disruption, across all three diseases.
- Open access
- 6 cites
Mendelian randomization and multiomics analyses identified 19 druggable targets for Alzheimer's disease, including protective variants in EPHX2, in individuals of European and African ancestry.
- Open access
Hepatic expression of APOE3 Christchurch reduces amyloid-β burden and AD pathologies in APOE4-expressing APP/PS1 mice.
- 1 cites
A single Centiloid cutoff of 18 best distinguishes amyloid positivity in PET scans across diverse studies, with a high predictive value for visual reads.
- 7 cites
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Journals this month
- bioRxiv6131
- medRxiv1703
- PNAS447
- Sci Adv354
- JAMA262
- Environ Res230
- BMJ182
- Environ Pollution165
- Nat Commun161
- Science141
- Nature138
- Lancet128
- Cell Rep120
- NEJM119
- mBio107
- Plant Cell Environ107
- Curr Biol106
- J Exp Bot106
Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3