Nature Reviews Cancer
Nature Portfolio · Oncology · ISSN 1474-175X, 1474-1768
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Latest in Nat Rev Cancer
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Mapping the dark proteome in cancer reveals thousands of previously uncharacterized proteins with potential roles in cancer biology and therapy.
Metabolic factors influenced by CAR design, manufacturing, and host diet are key to improving CAR T cell efficacy against solid tumors.
Activation of gasdermin-induced pyroptosis in cancer cells can trigger antitumour immunity with only a fraction of cells undergoing pyroptosis.
Cancer-associated extracellular vesicles and particles are linked to widespread systemic dysfunction across multiple organs, contributing to host morbidity and mortality.
Early-onset colorectal cancer (EOCRC) under age 50 is increasing globally, with lifestyle and early-life gut microbial exposures linked to its rise.
Emerging 3D multi-omics tumour atlases have the potential to reveal novel biomarkers and mechanisms of tumour evolution, advancing cancer diagnosis and treatment strategies.
Replication stress in cancer is linked to genomic instability and tumor progression, with ATR-CHK1 pathway playing a key role in preventing catastrophic genome fragmentation.
Viral mimicry escape is a necessary feature of malignant transformation, enabling cancer cells to evade immune responses and promote tumor progression.
Population genetics reveals that cancer evolution can be quantitatively understood through models of mutation, selection, and drift, transforming genomic data into evolutionary insights.
Single-cell technologies reveal how genotypes and phenotypes co-evolve in human tissues, uncovering mutant-specific traits and therapeutic vulnerabilities in cancer.
Neutrophils predominantly promote tumor growth and metastasis in cancer, but can also mediate tumor cell killing depending on environmental cues.
DDR deficiencies and inhibitors significantly boost cancer immunotherapy responses by generating immunogenic signals that activate immune pathways.
Viral exposures beyond oncogenesis can enhance cancer immunity, with endogenous retroviruses and microbiome-associated phages playing protective roles.
Genomic and epigenomic profiling reveal over 40 molecular subtypes of acute lymphoblastic leukemia, enhancing classification and informing treatment strategies.
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Topics moving, week to 23 Oct 2026
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