Emeritus professors' contributions could be greatly increased with better support, which is currently hindered by ageism.
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EMBO Reports
Springer Nature · Cell & Molecular Biology · ISSN 1469-221X, 1469-3178
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Scarcity may enhance intellectual discipline and ingenuity in research, whereas easy access to resources might undermine their thoughtful use.
- In the news
Incorporating replication of key experiments into scientific publishing is essential to address the replication crisis in academia.
- In the news
Type I interferons inhibit NLRP1-driven PANoptosis by reducing NLRP1 expression through a TLR4-TRIF-IRF3 signaling pathway.
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Gαi2 promotes microtubule-driven neurofilament incorporation to stabilize nascent axons in the developing chick spinal cord.
- Open access
Sox3 is essential for maintaining the actin core of hair cell stereocilia, with its absence causing progressive disassembly and hearing loss in mice.
- Open access
ALYREF binds to poly-ADP-ribose at double-strand breaks and delays repair in tumoral cells, with overexpression linked to genome instability.
Loss of ALC1 markedly sensitizes ovarian cancer cells to PARPi, including resistant and CCNE1-amplified tumors, with a wide therapeutic index.
TREX1 deficiency in murine lung and melanoma tumor cells causes a substantial, MRE11-dependent increase in short cytosolic DNA fragments from transcriptionally active regions.
Mammalian ER membranes are primarily composed of phosphatidylcholine and monounsaturated glycerophospholipids, indicating a highly compressible bilayer.
- Open access
Loss of C. elegans GRK-1 reduces isothermal tracking duration by affecting neuronal states in RIM and AVA interneurons.
- Open access
G6PD deficiency increases platelet counts by enhancing proplatelet formation through disrupted actin dynamics in humans and mice.
Miropin from Tannerella forsythia inhibits Porphyromonas gingivalis gingipains, reducing bacterial growth and virulence in periodontal disease models.
Viral infections can promote B-cell tolerance breakdown through shared immune mechanisms, increasing autoreactive B-cell survival and activation across diverse infection types.
Carmn is a conserved regulator of epithelial basal-cell stemness and Wnt/β-catenin signaling in exocrine glands, essential for tumor formation in mammary tissue.
- Open access
Notch activation silences Hedgehog signaling via an E2-E3-E3 ubiquitin ligase module to specify germline stem cell niche in Drosophila ovary.
- Open access
Loss of Prospero in Drosophila neuroblasts causes lineage-specific cell cycle defects linked to cyclin E misregulation and mitotic arrest, not dedifferentiation.
Phosphorylation of ZC3H14 by CDK12/13 is essential for nuclear speckle formation during zygotic splicing activation in mice.
Loss of Aim11 in mitochondria causes accumulation of assembly intermediates of cytochrome c oxidase and ATP synthase in yeast.
- Open access
Intestinal FXR agonists reduce obesity by suppressing appetite through leptin- and secretin-dependent mechanisms in diet-induced and db/db mice.
Loss of TBK1 function impairs the IFNβ-immunoproteasome pathway, leading to TDP-43 aggregation in ALS models, with a 50% reduction in immunoproteasome induction observed in Tbk1 heterozygous mice.
- Open access
Astrocytic cathepsin D facilitates α-synuclein processing and promotes Lewy neurite-like aggregate maturation in a neuron-astrocyte co-culture system.
Butyrate supplementation rescues maternal obesity-induced fetal cardiac abnormalities by enhancing PLEKHG3-actin interactions in mice and human cardiomyocytes.
A uORF in CAK1 represses Cak1 synthesis in yeast, reducing Cdk activation and viability of quiescent cells under low-nutrient conditions.
MPK3 phosphorylation at Serine 4 inactivates MYB4, enabling FIT-dependent iron uptake in Arabidopsis under deficiency conditions.
Phosphoglycerate kinase 1 (PGK1) forms a novel coat protein complex with AP2, promoting endocytosis by acting as a cargo adaptor and stabilizer of the AP2 complex.
- Open access
Sulf1 modulates TGF-β-dependent epicardial activation and inflammation, with its disruption causing regeneration defects and increased fibrosis in zebrafish hearts.
- Open access
Burkholderia thailandensis switches from T6SS-1 to T6SS-5 during phagosomal maturation, with T6SS-1 assembly declining as T6SS-5 expression increases.
- Open access
Set1 is essential for piRNA production and transposon silencing at telomeres in Drosophila germline, acting independently of its catalytic activity.
CpG methylation modulates DNA mechanics and chromatin organization by increasing DNA stiffness, weakening nucleosome wrapping, and promoting heterochromatin condensates.
Transcription factors often bind DNA without directly correlating with transcriptional output, and disordered domains complicate understanding their regulatory roles.
Interaction between BRCA1 exon 11 and TOPBP1 is essential for DNA end-resection during homologous recombination.
- Open access
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3