A telomere-to-telomere human genome benchmark achieves 99.4% accuracy, adding 701.4 Mb of previously missing autosomal and sex chromosome sequences.
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Moving in Cell and Nucleic Acids Research.
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A telomere-to-telomere human genome benchmark achieves 99.4% accuracy, adding 701.4 Mb of previously missing autosomal and sex chromosome sequences.
PanGBank provides precomputed pangenomes for over 4600 prokaryotic species, covering more than 393,000 genomes, enabling large-scale comparative genomics.
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The genome of Xiphinema index reveals a vertebrate-like epigenetic machinery and a unique plant-derived horizontal gene transfer linked to parasitism.
Cross-species analysis of bacterial transcript 3' ends uncovers diverse termination signatures and species-specific mechanisms in 32 human pathogens.
Billi accurately detects cyclic and nested genomic variants in pangenome graphs with an O(|V|^2(|V| + |E|)) algorithm, outperforming existing methods on complex structures.
RNAcomp2D enables simultaneous comparison of multiple RNA secondary structure prediction methods through a unified web interface.
Genomic analysis reveals TIP3-1 gene in Zostera japonica confers tolerance to salinity and heat, highlighting key adaptation mechanisms in intertidal seagrass.
LoL-align is significantly more sensitive than TM-align and Dali in detecting remote homologs, with 5-20 times faster alignment speed on benchmark datasets.
PlantGeneAnn achieves a new state-of-the-art F1 score of 0.856 at the exon level in plant gene annotation across 20 species, outperforming existing tools.
Small HK97-fold viral genomes linked to procapsids suggest bidirectional evolution between viruses and encapsulins.
PanTEon reveals that machine learning-based transposable element classifiers show markedly variable performance across TE superfamilies and eukaryotic lineages.
REMAG recovers more near-complete eukaryotic genomes than existing tools in metagenomic data, outperforming current methods in simulated and real datasets.
LOCALE achieves 4.5 times higher AUPRC than MetaGraph on petabase-scale DNA search with 10% genomic variation.
Nanopore sequencing with SomaGauss-SV detects high-frequency somatic structural variations in 71.79% of LSCC patients, revealing recurrent genomic alterations.
Gene identity and exon position primarily predict synonymous-variant pathogenicity, with a simple distance-to-exon-junction feature outperforming neural models at 0.84 accuracy.
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Topics moving, week to 22 Oct 2026