Lysosomal dysfunction causes microglia-specific epigenetic and transcriptional changes linked to neurodegenerative diseases, with a significant impact observed in Sgsh-deficient mice.
- 1 cited this week
Neuroinflammation and Neurodegeneration Mechanisms
Moving in Immunity, eLife, Nature Genetics and Neuron.
- Moved, week to 22 Oct 2026
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Progranulin deficiency causes lysosomal dysfunction that triggers maladaptive myeloid cell states via MITF/TFE transcription factors, impacting neurodegeneration.
- 1 cited this week
Deletion of SPI1 in microglia worsens amyloid pathology by reducing microglial response and phagocytosis in Alzheimer's disease models.
- Open access
- 5 cites
A disease-associated microglial subtype with elevated GPNMB expands with Alzheimer's pathology and depends on TREM2 for neuroprotection.
- Open access
- 22 cites
Sibling-derived microglia comprise up to 52% of microglial cells in marmoset brains, highlighting extensive hematopoietic chimerism within neural tissue.
- Open access
- 5 cites
Latest in Neuroinflammation and Neurodegeneration Mechanisms
Newest first · last 60 days
Microglia in human forebrain organoids mediate amyloid-β clearance, recruit CD8+ T cells via CCL4/5 signaling, and establish a neuroinflammatory feedback loop in Alzheimer’s disease models.
- Open access
A non-canonical reactive astrocyte state (Ast10) is linked to neuropathologies and cognitive decline in Alzheimer's disease across diverse human brains.
- Open access
- 14 cites
Amyloid clearance after aducanumab treatment is linked to reduced tau pathology and slower cortical atrophy in Alzheimer disease.
- Open access
Early infiltration of ischemia-conditioned Tregs at day 5 post-MCAO reduces BBB damage by suppressing neutrophil extracellular traps in ischemic stroke.
- Open access
Maternal type I interferon signaling causes TREM2 dysregulation and synaptic dysfunction in offspring hippocampus in a neurodevelopmental disorder model.
- Open access
- 2 cites
Oligodendrocytes actively support CNS function through metabolic provision, adaptive myelination, and repair, but become dysfunctional in aging and disease.
AI-based framework identifies approximately 1.5 million phenotype-associated cells from over 1,000 brains with Alzheimer's disease phenotypes, revealing key cell subpopulations and pathways.
- Open access
- 1 cites
A human iPSC-derived spheroid model reveals that remyelinated axons have thinner myelin sheaths after injury, advancing understanding of human myelin repair mechanisms.
- Open access
Wild type bone marrow-derived microglia-like cells prevent strain-dependent thalamic calcification in Csf1r mutant mice.
- Open access
- 7 cites
PLA2G2D in tumour-draining lymph nodes acts as a novel immune checkpoint that suppresses anti-tumour T cell responses, with inhibition reducing tumour growth in melanoma models.
- Open access
TRAM enables receptor-free myddosome formation, sustaining hours-long NF-κB activation and inflammatory gene expression in TLR signaling.
- Open access
Exogenous CoA acts as a weak TLR4 agonist that enhances IL-4 driven macrophage activation via MyD88 in vitro and in vivo.
- Open access
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3