Dreamlet enables fast, memory-efficient differential expression analysis of large-scale single-cell transcriptomics data, accurately identifying gene-trait associations across 150 Alzheimer's cases.
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Nature Communications
Nature Portfolio · General Science & Medicine · ISSN 2041-1723
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MKLN1 within the CTLH E3 ligase recognizes diverse substrates through multimodal engagement of acetylated, Arg, and C-degrons, revealing a versatile recognition mechanism.
- Open access
- 1 cites
Extensive genomic diversity in Desulfovibrio reveals species-specific traits linked to inflammatory diseases across 90 conditions and 32 countries.
Type I interferon promotes ILC2-to-ILC1 plasticity, contributing to radiation-induced lung injury in a mouse model.
- Open access
Microscopic dephasing in solid-state high-order harmonic generation is caused by carriers entering regions with enhanced electron-phonon scattering, leading to few-femtosecond coherence times.
Epithelial NF-κB activity promotes a protective Treg cell response that is crucial for resolving intestinal inflammation in colitis.
- Open access
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Microscopic dephasing in solid-state high-order harmonic generation is caused by carriers entering regions with enhanced electron-phonon scattering, leading to few-femtosecond coherence times.
Eighty-four high-risk antimicrobial resistance traits in MDR Salmonella are projected to increase by 2050, driven by socioeconomic, climate, and healthcare factors in China.
- Open access
Type I interferon promotes ILC2-to-ILC1 plasticity, contributing to radiation-induced lung injury in a mouse model.
- Open access
Stabilizing G-quadruplexes with pyridostatin reduces NF-κB-dependent inflammatory gene expression in lipopolysaccharide-stimulated mouse macrophages.
- Open access
Epithelial NF-κB activity promotes a protective Treg cell response that is crucial for resolving intestinal inflammation in colitis.
- Open access
Tailored shell growth and interfacial oxidation enable a highly efficient heavy-metal-free SWIR LED emitting at 1525 nm with over 55% PLQY.
Miro1 accumulation in skeletal muscle is linked to insulin resistance in patients with obesity and T2D, as shown in both humans and mouse models.
Resolving short-term meteorological variability with a daily glacier model predicts up to 25% greater mass loss in Svalbard and 5-10% more global sea-level rise than monthly models.
A movable magnetic topographic surface (MMTS) under electromagnetic field eradicates bacterial biofilms and promotes bone integration in vivo.
Small-molecule RIG-I agonists that directly activate the receptor by triggering CARD release were identified and optimized, inducing a robust interferon response.
Humans target 26% of freshwater fish species that represent nearly half of global fish morphological diversity, causing non-random erosion of ecological traits.
Bacillus species on human skin are linked to reduced mosquito attraction by reprogramming skin volatiles, with B. licheniformis and B. paralicheniformis significantly decreasing mosquito attraction in primates.
MKLN1 within the CTLH E3 ligase recognizes diverse substrates through multimodal engagement of acetylated, Arg, and C-degrons, revealing a versatile recognition mechanism.
- Open access
- 1 cites
Physical confinement in 3D environments physically constrains budding yeast, drastically prolonging cell cycle progression without triggering regulatory or stress responses.
- Open access
A graded, revisable framework for ICU-acquired pneumonia diagnosis incorporates clinical, imaging, and microbial data, moving beyond binary pathogen detection.
- Open access
Recurrent genomic driver alterations are identified in 97% of primary prostate tumors, revealing four distinct oncotypes with varying clinical outcomes.
- Open access
Earthquake early warning systems are essential for reducing seismic impact in growing populations of seismically active regions.
- Open access
Infants of mothers who received prenatal interpersonal psychotherapy have 0.62 standard deviations lower right hippocampal volume at 6 weeks compared to those in usual care.
- Open access
- 1 cites
Ryugu's aqueous environment was highly reducing, strongly alkaline, and had lower salinity than previously estimated, with pH 10.3–11.5 and Eh -0.5 to -0.8 V.
- Open access
Two Arctic endemic cod species, Arctogadus glacialis and Boreogadus saida, lived at 87-89°N during 48,000-35,000 years ago and reappeared at 12,000 years ago.
- Open access
Skeletal tissue composition at the amputation site influences osteoclast activation and regenerative strategies in axolotl limb regeneration.
Human-driven erosion has tripled sediment flux in Lake Iseo, preconditioning its delta for collapse and generating tsunamis with maximum run-ups of ~50 m and ~13 m during historic earthquakes.
Spatial transcriptomics reveals that fatal COVID-19 lung damage involves a progressive loss of endothelial cells, pneumocytes type I, and natural killer cells, with increased myeloid and stromal cells.
cPRIME enables endogenous mapping of genetic variant effects at RNA level, revealing that synonymous marker edits can alter RNA processing in diverse genomic contexts.
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3