Loss of NUS-1/DHDDS-1 in C. elegans disrupts N-glycosylation, causing ER stress, lysosomal collapse, and systemic lipopenia, linking glycosylation to lipid and lysosomal homeostasis.
Cell Reports
Cell Press · Cell & Molecular Biology · ISSN 2211-1247
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Polycystin-2 acts as a PERK-dependent calcium leak channel under ER stress to protect against myocardial infarction in mice.
METTL4 and MRG1/2 co-regulate alternative splicing and promote thermomorphogenesis in Arabidopsis, with mutants showing reduced hypocotyl elongation at 28°C.
RUNX1-ETO levels determine endothelial reprogramming and pre-leukemic growth in human ESC-derived myeloid progenitors, with reprogramming being concentration-dependent and irreversible.
Loss of NUS-1/DHDDS-1 in C. elegans disrupts N-glycosylation, causing ER stress, lysosomal collapse, and systemic lipopenia, linking glycosylation to lipid and lysosomal homeostasis.
Sequential activation of TPRX1 and HERVL defines the stepwise progression toward human 8-cell-like cells in vitro.
- Open access
Early-life high-fat diet causes a precocious maturation of vagal satiation signaling in mice, with adult females showing increased overconsumption of energy-dense foods.
The COX2-PGE2-PKA axis inhibits mtDNA-dependent STING activation, reducing antiviral immunity during herpes simplex virus type 1 infection.
Ubiquitin-dependent fate control and isoform diversity safeguard ZUP1, a key ubiquitin chain-editing enzyme, maintaining RPA turnover on ssDNA in cells.
- Open access
STIM1 and STIM2 differentially regulate synaptic efficacy, with STIM1 mainly supporting excitatory and STIM2 critical for inhibitory synapses in hippocampal neurons.
GP33, a small membrane protein from the archaeal virus HFTV1, forms pores that disrupt membranes, providing insight into archaeal virus lysis mechanisms.
Cross-species analysis of bacterial transcript 3' ends uncovers diverse termination signatures and species-specific mechanisms in 32 human pathogens.
- Open access
ICAM-1 functions as a key receptor for EMCV entry, with high-affinity binding to viral proteins VP1 and VP2, and is essential for infection in human and mouse cells.
Sequential stepwise methylation maintains H3K27 tri-methylation in Polycomb domains during DNA replication in human cells.
TM6SF2 at ER membrane contact sites activates RAB7 to enable endolysosomal VLDL secretion and maintains Golgi structure in liver cells.
Topoisomerase depletion in C. elegans preferentially inhibits convergent gene expression and globally hinders transcription elongation, leading to shorter transcripts and poly(A) tails.
TDP2-mediated DNA repair is essential for timely regulation of early response gene transcription in cortical neurons, with Tdp2 deletion causing ERG overexpression and circuit dysfunction.
- Open access
VEGF-C-driven lymphangiogenesis enables durable complete responses to oncolytic virotherapy in mouse melanoma models.
- Open access
Genomic analysis reveals TIP3-1 gene in Zostera japonica confers tolerance to salinity and heat, highlighting key adaptation mechanisms in intertidal seagrass.
- Open access
C12A6 antibody cross-neutralizes HSV-1, HSV-2, and PRV by targeting a conserved epitope on glycoprotein B's Domain I, providing substantial but incomplete protection.
Reactive astrocyte-like tumor cells with mesenchymal and injury-response signatures are enriched after radiotherapy and persist in recurrent glioblastoma in a mouse model.
- Open access
Reducing ataxin-2 activates stress-adaptive metabolic pathways in neurons and astrocytes, providing broad protection against TDP-43 toxicity in ALS models.
- Open access
Lymph node-tumor ecosystem remodeling during gastric cancer metastasis involves dynamic immune cell changes and is linked to specific molecular pathways.
- Open access
The NuRD complex modulates RNA polymerase III activity at highly expressed tRNA gene clusters, influencing the cellular tRNA pool's dynamic range.
- Open access
CRHR1 signaling in PVT neurons activated by early-life adversity is essential for sex-specific disruptions of adult reward behaviors, with deletion normalizing these behaviors in mice.
Inhibiting the right dorsolateral prefrontal cortex enhances unsupervised statistical learning in adults by 95 participants.
- Open access
Lipid droplets serve as the site of VLCFA activation by Fat1, with VLCFAs preferentially partitioning into LDs and Fat1 targeting LD surfaces via an amphipathic helix.
NONO prevents transcription-replication conflicts during replication stress by restraining BRD4-dependent transcription elongation, reducing genomic instability.
Inhibition of NHR-180 enhances mitochondrial function and development in atfs-1(null) C. elegans under mitochondrial stress.
Cingulate thrombospondin 4 (THBS4) is downregulated after peripheral neuropathy and its overexpression alleviates pain hypersensitivity and anxiodepression in the ACC.
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
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- Dementia and Cognitive Impairment Research3