The 2026 AHA/ACC/ADA/ASN guideline updates and expands management strategies for cardiovascular-kidney-metabolic syndrome, targeting clinicians caring for affected patients.
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Circulation
Lippincott Williams & Wilkins · Clinical Medicine · ISSN 0009-7322, 1524-4539
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Sirolimus-eluting balloon with provisional stenting is noninferior to systematic drug-eluting stent implantation for target vessel failure at 1 year in de novo coronary lesions.
- 3 cited this week
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Understanding myosin structure-function relationships has enabled the development of targeted therapies for hypertrophic cardiomyopathy.
Coronary computed tomography angiography-derived fractional flow reserve (FFR-CT) predicts future cardiovascular events, with lower values linked to higher risk in a large nationwide cohort.
Functional analysis of 13,403 KCNQ1 variants identified 1,757 with strong pathogenic evidence linked to long QT syndrome and arrhythmia risk.
Genetic evidence for dilated cardiomyopathy (DCM) has expanded, with 35 high-evidence gene-disease relationships identified in the latest assessment, up from 19 five years ago.
Radiation-associated coronary artery disease (RACAD) occurs within 1 to 20 years after thoracic radiotherapy and is linked to radiation dose and patient risk factors.
Lactylation of HNRNPK at lysine 405 in myocardium increases after reperfusion and promotes Jag2 splicing changes that exacerbate inflammation and injury.
Aficamten improves diastolic function and alters cardiac structure in patients with symptomatic nonobstructive hypertrophic cardiomyopathy, with significant changes observed at 36 weeks.
Women have a higher prevalence of chronic kidney disease than men, but are less likely to progress to kidney failure or receive transplantation, highlighting sex differences in outcomes.
Aficamten significantly improves multiple clinical measures in 53% of patients with nonobstructive hypertrophic cardiomyopathy compared to 14% on placebo.
Cardiovascular disease became the leading cause of death among Hispanic adults in the United States in 2022, with disparities widening in risk factors and disease burden.
Point-of-care high-sensitivity troponin testing reduces emergency department length of stay by 13%, or approximately 47 minutes, in patients with possible acute coronary syndrome.
Quantitative mitral regurgitation thresholds in transthyretin amyloid cardiomyopathy are substantially lower than current guidelines, improving outcome prediction.
PUS7-mediated pseudouridylation of TGFBI is linked to pulmonary hypertension progression in lung tissues.
Inactivation of ANGPTL8 alone reduces plasma LDL cholesterol by approximately 20% in mice, with effects dependent on endothelial lipase and ANGPTL3.
Asundexian added to antiplatelet therapy does not significantly increase major or overall bleeding in patients with noncardioembolic ischemic stroke or high-risk TIA.
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
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