Multimodal biomarkers combining liquid biopsy, AI-based imaging, and tumor immune profiling may improve early detection and immunotherapy assessment in hepatocellular carcinoma.
- Open access
Frontiers in Genetics
Frontiers Media · Genomics & Bioinformatics · ISSN 1664-8021
- Impact (2-yr)
- 3.0
- h-index
- 173
- Open access
- 100%
- Works
- 17.3K
- Papers this month
- 38
Track Front Genet in JClubFree on iPhone and Android · in the app, the list is My Journals
Rebuilt
Latest in Front Genet
Newest first · last 60 days
CombinedNet transcriptomic scoring method shows moderate-to-high concordance with existing pathway activity measures and recovers promoter-inhibitor balance in cervical cancer data.
- Open access
Sixty percent of individuals with Fabry disease in Brazil, Argentina, and Colombia have GLA variants that may respond to migalastat treatment.
- Open access
MetaSVM, MetaLR, and ESM1b outperform traditional tools in predicting YWHAG missense variant pathogenicity, with MetaSVM showing the best overall performance.
- Open access
A possible postzygotic mosaic GNAS variant in one child with POH was associated with localized ossification and slow recurrence over five years.
- Open access
A heterozygous missense variant c.391C>T (p.Arg131Cys) in FHL2 is linked to endocardial thickening in a 30-day-old infant with severe dilated cardiomyopathy.
- Open access
A chemotherapy-suppressed proliferative program in malignant neuroblasts predicts adverse prognosis in neuroblastoma.
- Open access
The 23 autosomal STR loci show high polymorphism and a cumulative power of exclusion of 0.9999957 in the Shenzhen Han population.
- Open access
m 6 A modification plays a significant role in lipid metabolism and related diseases, with regulators like METTL3 and METTL14 involved in disease development and progression.
- Open access
A novel XK c.484C > T (p.Gln162Ter) variant is linked to McLeod syndrome in a Chinese Han family, expanding the genetic and ethnic spectrum of the disease.
- Open access
A pilot GWAS of ischemic heart disease with hypertension in Kazakh individuals identified ZFHX3 as the strongest suggestive locus but found no variants reaching genome-wide significance.
- Open access
Shenqi Fuzheng Injection may target Caspase-3 and Caspase-8 to reduce apoptosis in cancer-associated muscle wasting, with key components showing strong binding affinity.
- Open access
Biologically informed machine learning enables stage-aware genomic risk stratification in prostate cancer, integrating inherited susceptibility and tumor biology.
- Open access
Pathogenic variants in 2.73% of the Slovenian population are found in 84 medically actionable genes, with an additional 0.48% of novel likely pathogenic variants.
- Open access
A practical implementation roadmap enables ISO 9001:2015-certified biobanks to adopt ISO 20387:2018 within 17–20 weeks, addressing biobank standardization needs.
- Open access
Bioinformatic prediction, qCLASH, and AlphaFold3 reveal distinct, non-overlapping layers of the miR-214-3p-mRNA interactome in mouse lung tissue.
- Open access
Silencing HOTAIR in SONFH-BMSCs enhances osteogenic differentiation by activating the Wnt/β-catenin pathway and suppresses adipogenic differentiation.
- Open access
PPC-positive endometrial cancers are linked to increased stromal/mesenchymal activity and decreased cytotoxic/antigen-presentation transcriptional programs, correlating with poorer outcomes.
- Open access
Orchid root microhabitat self-organization is driven by complex interactions among roots, soil, microorganisms, and root exudates, forming a dynamic system crucial for orchid ecology.
- Open access
Matrix-product-based kernels improve genomic prediction of genotype-by-environment interactions, with up to 13.2% higher predictive accuracy than Hadamard kernels in wheat and rice datasets.
- Open access
HSP70 depletion in HeLa cells causes over 90% reduction in transcript and protein levels, leading to a 1.8-fold increase in misfolded/aggregated proteins.
- Open access
Annexin A2 operates within a multipath interaction network influencing neurological diseases, with many signaling outputs arising from membrane trafficking and receptor organization.
- Open access
Fetal copy number variants are detected in 4.5% of low-risk pregnancies with non-structural ultrasound abnormalities, with variation across different ultrasound markers.
- Open access
DeepFS achieves 89.45% accuracy and 0.9647 AUC in diagnosing Alzheimer's disease from brain tissue transcriptomic data.
- Open access
A 7-gene M2 macrophage-associated signature predicts osimertinib resistance in lung adenocarcinoma, with RRBP1 showing the strongest link to survival.
- Open access
Two recurrent founder alleles account for 39.2% of EYS variants in an Eastern European and Northern Asian cohort with retinitis pigmentosa.
- Open access
singIST enables standardized, quantitative comparison of disease model and human single-cell transcriptomic data, revealing biological recapitulation across pathways, cell types, and genes.
- Open access
A 28-year-old Chinese woman was diagnosed with both Wilson disease and tuberous sclerosis complex, marking the first reported case of their co-occurrence.
- Open access
Locus-, cell-, and stage-specific epigenetic reprogramming, not uniform changes, most consistently underpins mechanisms of chronic pain across models.
- Open access
Track Front Genet in JClub
Browse JClub
Journals this month
- bioRxiv6131
- medRxiv1703
- PNAS447
- Sci Adv354
- JAMA262
- Environ Res230
- BMJ182
- Environ Pollution165
- Nat Commun161
- Science141
- Nature138
- Lancet128
- Cell Rep120
- NEJM119
- mBio107
- Plant Cell Environ107
- Curr Biol106
- J Exp Bot106
Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3