Nature Reviews Molecular Cell Biology
Nature Portfolio · Cell & Molecular Biology · ISSN 1471-0072, 1471-0080
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Latest in Nat Rev Mol Cell Biol
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Atomic, structural, and molecular insights reveal how GPCRs translate extracellular cues into intracellular signals, advancing understanding of their complex signalling mechanisms.
CMA regulates a broad range of physiological functions and its dysfunction in ageing and disease causes cellular changes beyond damaged protein accumulation.
Most large extracellular vesicles (lEVs) exceeding 200 nm originate from the plasma membrane and include diverse subtypes with distinct biogenesis pathways.
Transient, dynamic assemblies govern gene regulation complexes, with activity controlled through kinetic exchange rather than static structures.
The outer kinetochore's KMN complex is essential for microtubule binding and spindle assembly checkpoint regulation during chromosome segregation.
Recent advances reveal the complete structure and function of the inner kinetochore and the organization of centromeric chromatin, enhancing understanding of chromosome segregation.
Necroptosis is classified into extrinsic and intrinsic subtypes, with distinct mechanisms of trigger sensing and signal integration, involving 3 membrane-bound and 1 intracellular sensor.
DNA repair pathway choice between homologous recombination and non-homologous end joining is regulated by DNA end resection and specific repair factors.
Single-molecule genomics (SMG) enables genome-wide profiling of regulatory factors on individual DNA molecules, revealing molecular heterogeneity and co-occurring regulatory events.
High-resolution cryo-electron microscopy reveals dynamic assembly processes in RNA polymerase II transcription initiation, with key complexes like TFIID and Mediator playing crucial roles.
Plants activate complex molecular and cellular mechanisms, including heat shock factors and biomolecular condensates, to acclimate to heat stress, enabling survival under rising temperatures.
High-resolution imaging reveals complex, dynamic architecture of mammalian nucleoli essential for ribosome biogenesis.
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Topics moving, week to 23 Oct 2026
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