Conditional regulation of the CTLH E3 ligase complex is linked to ribosome biogenesis through a proteome-wide C-degron pathway.
Molecular Cell
Elsevier BV · Cell & Molecular Biology · ISSN 1097-2765, 1097-2765
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Adaptamers, a compact RNA switch, enable precise, reversible control of transgene expression via small-molecule-dependent ADAR-mediated RNA editing in vivo.
Deep learning reveals that cis-regulatory elements operate through a two-layered logic involving binding-level and transcriptional-level integration, following a "multiplication plus saturation" pattern.
Structural compatibility alone is insufficient for accurate protein-protein interaction prediction, especially in cases involving dynamics, weak co-evolutionary signals, or cellular context.
Disruption of OTULIN-LUBAC interaction in mice increases Met1-Ub accumulation at TNF receptor complexes, enhancing NF-κB signaling and sensitivity to TNF-induced toxicity.
Dorsal clusters in vivo enhance gene expression by increasing polymerase loading without affecting transcriptional bursting in Drosophila embryos.
dsRNAscan predicts 5 million human dsRNAs, with 2.4 million high-confidence predictions enriched at dsRNA-binding protein sites, revealing extensive dsRNA presence in the human genome.
AI may revolutionize molecular biology by revealing mechanistic possibilities beyond scientists' assumptions, exposing intellectual blind spots, rather than always providing correct answers.
Artificial intelligence has the potential to significantly accelerate discovery and improve data analysis in molecular biology research.
Viral infection and cellular stress induce ribosome remodeling that enhances specific mRNA translation, with rpL40 recruited to specialized ribosomes during infection.
ZC3H18 interacts with splicing factors to stimulate first intron splicing in human cells, and disruption of the CBC-ARS2-ZC3H18 axis corrupts this process.
AI-guided de novo protein design can now create programmable components that drive complex biological behaviors beyond simple molecular interactions.
AI now enables the design of de novo genome-editing enzymes, expanding beyond initial predictive applications in genome engineering.
AI models are increasingly being exploited to interpret large-scale single-cell genomics datasets, especially as atlas efforts and multiomic technologies expand.
AI-enabled RNA design becomes scalable and programmable by leveraging tertiary structure to interpret function and guide sequence generation.
unZipro achieves a 61% success rate in identifying high-activity protein variants from minimal libraries across nine diverse proteins.
State, a machine learning model, predicts single-cell transcriptome responses to perturbations across diverse cellular contexts.
Design elements and a checklist enable the development of interpretable foundation models in molecular biology that are as powerful as they are understandable.
Extrachromosomal DNA hubs create an electrochemical environment that reduces GSSG to GSH, forming a protective "cloud" around ecDNA in human cancer cells and mouse models.
DND1-NANOS3 complex represses key mRNAs via a heptamer motif in Mus musculus primordial germ cells, recognizing the AUGAAUU sequence in 3' UTRs.
dsRNAscan uncovers putative dsRNA-forming sequences in the human genome, revealing a hidden human dsRNAome not detected by traditional methods.
Mitochondrial DNA is tethered to the surface of select mammalian cells and is cleared by DNASE1L3, with increased surface DNA linked to autoimmune risk.
Cryo-EM structures reveal how the MSL complex specifically acetylates H4K16 in nucleosomes during active catalysis in Drosophila.
ATM prevents pathological repriming at oxidative DNA lesions, and its absence leads to DNA gaps that cause PARPi sensitivity in mammalian cells.
STING engages PKR to induce lysosomal cell death in lung ischemia-reperfusion injury in mice and rats.
PARP1-mediated ADP ribosylation of METTL3/14 forms a negative feedback loop regulating m6A methylation in human cells.
Reverse transcribed ssDNA from retrons derepresses toxin translation, enabling bacterial defense against phages without detectable msDNA in the absence of infection.
Structural analysis reveals that large serine integrases use conformational changes and RDF-mediated repositioning to control DNA recombination directionality, with distinct complexes for integration and excision.
TEtrans, a tumor-enriched, gene-independent class of TE-derived transcripts, predominantly composed of TE sequences, are identified across pan-cancer samples.
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