Transient alterations of H3K27me3 in C. elegans persist for many generations under selective pressure, affecting fertility in wild-type descendants.
- Open access
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EMBO Journal
Springer Nature · Cell & Molecular Biology · ISSN 0261-4189, 1460-2075
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Cryo-EM structures reveal ATP-driven conformational changes in Candida glabrata Cdr1 that facilitate drug efflux and itraconazole binding.
Golgi-associated tethers in Saccharomyces cerevisiae capture vesicles from specific intra-Golgi recycling pathways, with GARP tethering vesicles dependent on AP-1 and Ent5 adaptors.
USP28 regulates Golgiphagy by stabilizing TM9SF3, and its inhibition suppresses breast cancer growth in models.
Microtubule pushing forces are essential for preventing spindle stalling, enhancing robustness, and facilitating alignment alongside cortical pulling in diverse cell types.
- Open access
Electrostatic attraction alone can compact and sequester fragmented chromatin during apoptosis, preventing DNA release into extracellular vesicles.
- Open access
Bicon-seq identifies Gas5 as a highly conserved, essential lncRNA associated with NUP98::KDM5A onco-condensates in AML cells.
- Open access
Reduced distance between pre-mRNA 3' cleavage and transcription termination correlates with increased gene expression in colorectal cancer cells.
- Open access
Lateral actomyosin cables cooperate with apical purse strings to drive 3D cell shape changes and planar cell-cell intercalations, optimizing epithelial wound healing in Drosophila wing discs.
Progressive loss of CD24 and CD27 marks the differentiation of CD11c(+) atypical B-cells from memory B-cells after malaria infection, culminating in late ABCs with distinct markers.
miR-744-5p inhibits late-stage Salmonella intracellular replication by modulating connexin 43, which maintains Golgi organization and vacuole positioning.
M-CDK phosphorylation of DNA Pol α triggers a switch from canonical to recombination-dependent DNA synthesis in yeast cells with under-replicated DNA.
bcd mRNA translation is tightly controlled in space and time during Drosophila oogenesis and early embryogenesis, with translation restricted to the anterior pole and regulated by P bodies.
Reciprocal coupling between EMT initiation and BMP signalling mediated by SNAI2 and SMAD1 drives collective cell invasion in chick tissues.
Cellular senescence is now recognized as a complex stress-response program that actively influences tissue homeostasis, aging, and disease, with causal roles demonstrated in mouse models.
AHA, a conserved archaeal ribosome-associated protein, supports ribosome hibernation and shares evolutionary links with bacterial HPF and eukaryotic AMPKγ.
- Open access
Ped1, a dual-function phage protein from Pseudomonas aeruginosa phage PaoP5, degrades DNA and inhibits replication by targeting DnaB.
Lepr+/Glp1r+ hypothalamic neurons retain leptin sensitivity and limit hyperphagia and weight gain in diet-induced obesity, despite widespread leptin resistance.
Calreticulin mediates glycan-dependent transfer of MHC-I from TAPBPR to tapasin, revealing a glycan-surveillance mechanism in ER quality control.
Target-directed microRNA degradation (TDMD) influences cellular states and therapy resistance in breast cancer, with 19 substrates identified, including miR-29b-3p and miR-30c-5p.
Loss of Erbin in renal tubular cells increases susceptibility to AKI and worsens renal fibrosis in mice, with levels decreased in human CKD samples.
Distinct tau polymorphs in Alzheimer’s disease, PSP, and DLB associate with unique protein interaction networks, with 493 high-confidence interactors identified.
- Open access
Anti-CD137 monoclonal antibodies suppress germinal center responses in mice by increasing the immunosuppressive activity of follicular regulatory T-cells.
Clustering of host N-glycans by MIC1/4/6 complex is essential for Toxoplasma gondii rhoptry discharge, dependent on host cholesterol and glycans.
Brca1 coiled-coil domain mutants retain the ability to suppress Group 1 tandem duplications in mouse cells and tumor models despite impaired homologous recombination functions.
- Open access
Full-length, membrane-anchored perforin-2 is required for antigen escape into the cytosol in dendritic cells, not the proteolytically released ectodomain.
Hierarchical transcription factor networks regulate macrophage identity, activation, and responses, with secondary factors shaping stimulus-specific transcriptional programs.
Pol δ replaces Pol ε to synthesize and proofread nascent leading strands, mediating tolerance to araA and araC in the eukaryotic replisome.
Mitotic slippage-induced whole-genome duplication causes widespread nuclear instability in polyploid cells.
- Open access
CDC42 regulates reactive oxygen species to control Paneth cell identity and antimicrobial function in the small intestine.
- Open access
Presynaptic accumulation of APP-CTFβ is linked to increased synaptic vesicle docking and network hyperexcitability in Alzheimer's disease.
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3