Hereditary hemorrhagic telangiectasia affects 1 in 5000 individuals and causes high rates of bleeding, anemia, and serious organ complications in the US.
- 1 cited this week
- Open access
Blood
Elsevier BV · Clinical Medicine · ISSN 0006-4971, 1528-0020
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- 1.6
- h-index
- 635
- Open access
- 26%
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- Papers this month
- 105
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CD19 CAR T-cell therapy without lymphodepletion shows promising safety and efficacy in pemphigus vulgaris patients, with significant disease improvement in all four cases.
- Open access
- 4 cites
Latest in Blood
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Adding midostaurin to low-dose cytarabine and venetoclax improves overall survival in older patients with FLT3-ITD AML, with a median of 24.2 months versus 8.8 months.
A double reporter strategy identified a non-migratory subset of highly pure, platelet-biased long-term hematopoietic stem cells in the bone marrow niche.
High-titer FVIII inhibitors developed in two hemophilia A patients after ASC618 gene therapy, remaining nearly two years post-infusion despite declining titers.
21% of newly diagnosed AML patients harbor RAS mutations, with NRAS mutations showing higher prevalence of Q61 hotspots and multiple RAS mutations occurring in 23%.
TCR T cells targeting IgA- and IgG-expressing multiple myeloma eliminate HLA-A∗02:01+ MM cells in vitro and in vivo, showing promise for therapy in about 40% of European descent patients.
- Open access
- 1 cites
Navitoclax plus ruxolitinib significantly increases the proportion of patients with ≥35% spleen volume reduction at week 24 in untreated myelofibrosis, reaching 63.2% versus 31.5%.
- Open access
IL-6 receptor inhibition during cellular immunotherapy enhances cytolytic CD4+ T-cell differentiation, including Eomes+ subsets linked to improved antitumor effects.
Daratumumab monotherapy achieves a 75% hematologic response rate and a 65% 6-month overall survival in patients with stage IIIB AL amyloidosis.
Immunoglobulin heavy chain constant domains are identified as promising targets for TCR-based therapy in multiple myeloma, with high-avidity T cells recognizing IgG- or IgA-expressing cells.
Erythroblasts produce lipid mediators that regulate neutrophil development and function, with Alox15-derived resolvin D5 influencing neutrophil responses in mice.
The NG2-ITGA4 axis promotes leukemic aggressiveness in KMT2A-r B-ALL and can be targeted with natalizumab.
Rapid peak cilta-cel expansion is linked to increased risk of delayed neurotoxicity in patients with relapsed/refractory multiple myeloma.
Iron deficiency in female mice increases arterial nitric oxide signaling by reducing endothelial holo-α-globin, a process reversible with vascular iron repletion.
Ambient oxygen exposure during ex vivo handling rapidly disrupts amino acid homeostasis and impairs human hematopoietic stem and progenitor cell engraftment.
Activating PPM1D mutations are present in 3.1% of MPN patients and PPM1D overexpression is common in most PPM1D wild-type cases.
Germline DDX41 variants in MDS are linked to a 57% reduction in 2-year relapse incidence after transplantation compared to wild-type patients.
KPNA2-mediated MYC nuclear import significantly enhances CAR-T cell memory and antitumor efficacy in preclinical models.
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Journals this month
- bioRxiv6244
- medRxiv1789
- PNAS447
- Sci Adv354
- JAMA268
- Environ Res246
- BMJ196
- Nat Commun173
- Environ Pollution167
- Nature151
- Applied & Environ Microbio145
- Science141
- Lancet128
- Cell Rep127
- NEJM119
- Plant Cell Environ118
- J Exp Bot107
- mBio107
Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3