Inflammatory Bowel Disease
Moving in eLife, Gut and Nature Communications.
- Moved, week to 22 Oct 2026
- 3
- Papers in 60 days
- 52
Rebuilt
Moved this week
Distinct pediatric intestinal cell states at diagnosis predict Crohn's disease severity and response to anti-TNF therapy, with treatment shifting toward a more refractory adult-like profile.
- Open access
- 5 cites
Epithelial NF-κB activity promotes a protective Treg cell response that is crucial for resolving intestinal inflammation in colitis.
- Open access
Latest in Inflammatory Bowel Disease
Newest first · last 60 days
Epithelial NF-κB activity promotes a protective Treg cell response that is crucial for resolving intestinal inflammation in colitis.
- Open access
Genetic deletion of Zbtb44 causes spontaneous colitis and rectal prolapse in mice, with Zbtb44 -/- T cells showing increased IFN-γ expression.
Persistent elevation of faecal calprotectin >70 µg/g in asymptomatic first-degree relatives predicts presymptomatic Crohn's disease with 89% sensitivity and 94% specificity.
- 6 cites
Molecular features detectable years before clinical IBD diagnosis suggest a preclinical phase with potential for early intervention.
- Open access
CD19-targeted CAR T cell therapy can induce long-term remission of intestinal inflammation in ulcerative colitis, revealing a key role for mucosal B cells and plasmablasts.
- 1 cites
B cells with gut-homing markers and proinflammatory functions are increased at the asymptomatic stage in mice and patients susceptible to ICI-colitis.
- Open access
C. albicans-specific Th17 cells are shared across oral and gut mucosa, with significant enrichment in Crohn's disease, linking commensal fungi to intestinal inflammation.
- Open access
A machine learning scoring system using metabolic biomarkers achieves an AUC of 0.910 for IBD diagnosis, surpassing traditional fecal calprotectin tests.
- Open access
TL1A-activated T cells induce a distinct rectal mucosal signature in Crohn's disease patients with perianal fistulising disease, independent of inflammation and anti-TNF therapy.
- Open access
- 6 cites
Family history of colorectal cancer increases CRC incidence similarly in IBD patients and the general population, especially with multiple affected relatives, but the relative impact is weaker in IBD.
- Open access
Endothelial cell-intrinsic NOD2 signaling is essential for T cell recruitment and immune memory formation in the intestine, with NOD2 driving effector and memory T cell accumulation.
- Open access
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Journals this month
- bioRxiv6244
- medRxiv1789
- PNAS447
- Sci Adv354
- JAMA268
- Environ Res246
- BMJ196
- Nat Commun173
- Environ Pollution167
- Nature151
- Applied & Environ Microbio145
- Science141
- Lancet128
- Cell Rep127
- NEJM119
- Plant Cell Environ118
- J Exp Bot107
- mBio107
Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3