Single-cell transcriptomics of mouse anterior segment development reveals 130,000 cells and key pathways driving trabecular meshwork and Schlemm's canal formation.
- 1 cited this week
- Open access
eLife
eLife Sciences Publications Ltd · General Science & Medicine · ISSN 2050-084X
- Impact (2-yr)
- 2.1
- h-index
- 311
- Open access
- 100%
- Works
- 32.6K
- Papers this month
- 83
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Synaptic connectome analysis reveals diuretic hormone 44-expressing NSCs as key coordinators of physiology and behavior in the adult Drosophila brain.
- 1 on Bluesky
- Open access
Low-frequency tibial neuromodulation (1 Hz) excites bladder activity and alters urge perception in humans, demonstrating a frequency-dependent effect on bladder control.
- Open access
- 1 cites
Cardiolipin deficiency in mitochondria impairs electron transport chain function and causes steatohepatitis in mice and humans.
- Open access
- 3 cites
Threat intensity primarily drives innate decision-making in mice, with dominant individuals showing increased vigilance and risk aversion, as revealed by a new computational model.
- Open access
- 1 cites
Circadian and sleep disruptions in Drosophila melanogaster cause significant metabolic dysregulation, with mutant and constant darkness conditions showing impaired redox homeostasis.
- Open access
- 1 cites
Repurposed small molecule toxin inhibitors demonstrate pan-species neutralisation against Bothrops venoms in laboratory assays, with marimastat and DMPS providing the strongest protection.
- Open access
- 3 cites
Distinct pediatric intestinal cell states at diagnosis predict Crohn's disease severity and response to anti-TNF therapy, with treatment shifting toward a more refractory adult-like profile.
- Open access
- 5 cites
Sibling-derived microglia comprise up to 52% of microglial cells in marmoset brains, highlighting extensive hematopoietic chimerism within neural tissue.
- Open access
- 5 cites
Latest in eLife
Newest first · last 60 days
A spacetime attractor model explains how prefrontal cortex circuits implement planning through environment-embedded neural dynamics.
- Open access
Stable threat-value coding persists in prelimbic cortex populations despite 30 days of ensemble turnover during fear learning and retrieval in mice.
- Open access
Microglia in human forebrain organoids mediate amyloid-β clearance, recruit CD8+ T cells via CCL4/5 signaling, and establish a neuroinflammatory feedback loop in Alzheimer’s disease models.
- Open access
A transcriptional switch from KLF activators to repressors during early postnatal development regulates neuronal maturation in the mouse neocortex.
- Open access
- 1 cites
Bruce inhibits wing tissue growth in Drosophila by regulating autophagy-dependent activation of non-lethal caspase Dcp-1.
- Open access
Syntaxin11 deficiency inhibits CRAC channel priming, reducing calcium entry and gene expression in T lymphocytes independently of membrane trafficking, with implications for immune disorders.
- Open access
Multiple chromosome-specific mechanisms suppress axis protein deposition and DNA double-strand breaks within 20 kb of telomeres in Saccharomyces cerevisiae.
- Open access
RiboTRAP-seq reveals that anterior INT1 cells in C. elegans intestine are enriched for immune and stress response genes and are crucial for pathogen avoidance and survival.
- Open access
Individual dopaminergic neurons in Drosophila larva can induce diverse functions, including memory formation and locomotion modulation, with each neuron exhibiting a unique yet overlapping effect set.
- Open access
NeuroD1 does not induce microglia-to-neuron conversion in vivo, as all methods showed microglia retained their identity despite NeuroD1 expression.
PhDEF exhibits a major regulatory action in the petal epidermis, with significantly more prominent binding activity compared to the mesophyll in petunia flowers.
- Open access
Bovine mammary tissue can support infection and replication of diverse influenza A viruses, potentially facilitating viral co-infection.
Humans' ability to discriminate spatial patterns in the visual periphery is matched by models at a critical scaling that is approximately one-fourth for luminance compared to spectral energy features.
- Open access
Brown trout parr actively avoid cold water (≤8°C) through rapid behavioral responses, but do not avoid warmer water with temperature contrasts up to 8°C.
- Open access
AI literature tools should report the amount of information removed and the recoverability of omissions to ensure useful context preservation.
Bacterial stimuli induce C. elegans neural activity that is best described by an 8-dimensional hyperbolic space, revealing hierarchical organization in neural population dynamics.
Tsetse flies use subtle but highly efficient adaptations, including small teeth on the labellum and a strong proboscis retraction, to feed on diverse hosts without extraordinary forces.
- Open access
- 1 cites
Glycogen phosphorylase is non-essential for Plutella xylostella survival due to gluconeogenic compensation, despite potent in vitro inhibition.
- Open access
Rab5 and Rab11 regulate distinct developmental events in neural circuit assembly through endocytic trafficking pathways.
- Open access
Optimally designed perturbation inputs improve neural system identification accuracy by substantially outperforming conventional, intuition-based inputs in simulations.
- Open access
Allosteric disulfide bond switching in KIR2DL4 regulates HLA-G binding and endocytosis, with the Cys10-Cys28 bond controlling receptor activation in human NK cells.
- Open access
High JAK-STAT pathway activity in breast cancer correlates with improved immunotherapy response, especially in triple-negative breast cancer patients, serving as a predictive biomarker.
- Open access
- 1 cites
Reduced dorsal CA1 activity in Cntnap2 knockout mice impairs long-term retention of temporal associations in declarative memory.
- Open access
Low-frequency depression (LFD) at mammalian synapses results from synaptic vesicle undocking, not depletion of the readily releasable pool, and is immediately reversible by high-frequency stimulation.
- Open access
Human glutamine synthetase forms product-stabilized filaments that reduce catalytic specificity at physiological glutamine levels.
- Open access
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- bioRxiv6244
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- PNAS447
- Sci Adv354
- JAMA268
- Environ Res246
- BMJ196
- Nat Commun173
- Environ Pollution167
- Nature151
- Applied & Environ Microbio145
- Science141
- Lancet128
- Cell Rep127
- NEJM119
- Plant Cell Environ118
- J Exp Bot107
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3