IGF2BP2 promotes bladder cancer lung metastasis by enhancing complement C3 translation and remodeling the immune microenvironment.
Cellular & molecular immunology
Springer Nature · Cell & Molecular Biology · ISSN 1672-7681, 2042-0226
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Androgen-induced thymic involution promotes virtual memory CD8+ T cell expansion, aggravating ovarian inflammation in PMOS models.
Glutamate suppresses ILC2 responses and reduces allergic airway inflammation via the kainate receptor GluK2 in mice.
- Open access
An integrated cell death network (ICDN) framework reveals how apoptosis, pyroptosis, and necroptosis are coregulated in inflammatory tissues through common pathways.
Overexpression of p52 enhances persistence, effector functions, and tumor control of TCR-based T cells by activating noncanonical NF-κB signaling.
Geranylgeranyltransferase type II (GGTase II) is essential for B-cell activation, proliferation, and plasma cell survival, with its inhibition reducing autoimmune disease activity in mice.
IGF2BP2 promotes bladder cancer lung metastasis by enhancing complement C3 translation and remodeling the immune microenvironment.
BCR signaling strength determines the likelihood of VH gene replacement in peripheral B cells, with weaker signals increasing VHR frequency.
The H3K27me3-NR1D1-IFN-γ axis in lung-trained macrophages associated with early respiratory viral infection drives non-T2 asthma in childhood mice.
NLRP3 inflammasome interacts with multiple innate immune pathways and cell death mechanisms, shaping inflammatory responses during pathogen infection.
- Open access
Alterations in glycolysis, mitochondrial function, and mTOR signaling in lymphocytes are linked to the development of T-cell-mediated autoimmunity in diseases like MS, RA, and T1D.
- Open access
Blocking the m(6)Am methyltransferase PCIF1 in macrophages reduces colitis progression and protects enteric neurons from inflammation-driven degeneration.
MARCH2 and MARCH3 redundantly target FcγRI for K27-linked polyubiquitination and lysosomal degradation, limiting inflammatory responses in mice.
Platelet-derived serotonin activates macrophage epigenetic reprogramming via TGM2, promoting type 2 airway inflammation in mice and humans.
- Open access
ABTB1 functions as an E3 ubiquitin ligase that promotes STAT3 degradation, suppressing Th17 cell differentiation and reducing autoimmune inflammation.
αTIGIT-guided IL-15 mimetics significantly enhance antitumor activity and safety by targeting tumor-infiltrating lymphocytes in vivo.
Restoring IL-17D in glioblastoma reprograms CD93(+) antigen-presenting cells, extending survival by activating immune responses in mouse models.
PKP1 suppresses keratinocyte innate immune responses by sequestering DExD/H helicases, preventing excessive inflammation in healthy skin cells.
- Open access
HnRNPK deficiency in germinal center B cells markedly increases plasma cell differentiation and reduces germinal center B-cell numbers by up to 50%.
p97-mediated proteostasis is essential for late-stage thymocyte positive selection, with its loss causing a severe block in CD8+ lineage development in mice.
Disruption of FOXP3-T-bet interaction due to V408M mutation impairs Treg control of IFN-γ-driven Th1 inflammation in IPEX syndrome.
γδ and αβ CAR-T cells show comparable cytotoxicity but differ phenotypically, with γδ cells exhibiting lower glycolytic and oxidative phosphorylation capacities.
NLRC3 enhances antitumor immunity by inhibiting M-MDSC infiltration and function through a STING-dependent pathway, reducing tumor growth.
NADPH oxidases (NOXs) are key regulators of immune, metabolic, and environmental signals, with recent studies revealing their structures, regulatory mechanisms, and roles in disease, especially in immune and tumor contexts.
- Open access
The G2019S mutation in LRRK2 enhances NADPH oxidase-2 activity in neutrophils, improving bacterial infection control in mice by 2- to 3-fold.
Radiotherapy induces CD200(+) tumor-associated macrophages via STING pathway, which suppress eosinophil-mediated antitumor immunity in hepatocellular carcinoma.
Tumor cell-released autophagosomes (TRAP) program inflammatory CAFs to promote immune exclusion via C3a, with a 96% accuracy in distinguishing breast cancer patients.
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3