State predicts cellular perturbation effects across diverse contexts with over 30% improved discrimination on large datasets.
- 6 cited this week
What moved this week
Signals watches every paper JClub indexes for new citations, news coverage and Bluesky conversation. These are the ones that moved in the week to 22 Oct 2026 — with the app's AI summary on each.
- Papers moved
- 201
- Topics
- 13
- In the news
- 42
- On Bluesky
- 6
- Newly cited
- 36
Rebuilt
Movers
week to 22 Oct 2026
A biobank of 256 patient-derived tumour organoids reveals diverse gene dependencies across multiple cancer types, advancing precision oncology.
- 3 cited this week
- Open access
The 2026 AHA/ACC/ADA/ASN guideline updates and expands management strategies for cardiovascular-kidney-metabolic syndrome, targeting clinicians caring for affected patients.
- 3 cited this week
A telomere-to-telomere human genome benchmark achieves 99.4% accuracy, adding 701.4 Mb of previously missing autosomal and sex chromosome sequences.
- 5 cited this week
CD8+ T cell immunity enhances tumor cell susceptibility to cuproptosis, improving the effectiveness of inducers in overcoming immunotherapy resistance in preclinical models.
- 4 cited this week
- Open access
Switching to camizestrant at ESR1 mutation emergence during first-line therapy significantly extends progression-free survival in hormone receptor-positive advanced breast cancer, with a median of 16.8 months.
- 2 cited this week
A large-scale international effort created 665 next-generation patient-derived cancer models with 97.8% genetic and 95% epigenetic fidelity to original tumors, covering 25 cancer types.
- 2 cited this week
- Open access
China approves satricabtagene autoleucel, the first CAR T-cell therapy for solid tumors, for claudin 18.2-positive, HER2-negative gastric or gastro-esophageal junction cancer.
- 1 cited this week
- In the news
Molecular phenotypes and spatial archetypes reveal distinct CAF identities linked to tissue context, advancing precision targeting in cancer therapy.
- 3 cited this week
- Open access
AI model "Path2Space" predicts spatial gene expression from histopathology slides, accurately inferring thousands of genes and outperforming 21 established methods in breast cancer.
- 3 cited this week
- Open access
Complete Drosophila male CNS connectome reveals 138 dimorphic neuron types, highlighting sex-specific neural circuit differences at synaptic resolution.
- 3 cited this week
Obinutuzumab significantly improves disease activity in adults with active systemic lupus erythematosus, achieving a 23.1 percentage point higher response rate than placebo at week 52.
- 3 cited this week
Sirolimus-eluting balloon with provisional stenting is noninferior to systematic drug-eluting stent implantation for target vessel failure at 1 year in de novo coronary lesions.
- 3 cited this week
Global pain trajectories across the lifespan were established from over 6.1 million individuals in 118 countries, revealing higher late-life pain prevalence in low-HDI nations.
- 1 cited this week
- 1 on Bluesky
- Open access
MBS1 condensates in rice chloroplasts provide high-light tolerance by acting as a sunscreening mechanism, with overexpression increasing yield under stress conditions.
- 1 cited this week
Lysosomal dysfunction causes microglia-specific epigenetic and transcriptional changes linked to neurodegenerative diseases, with a significant impact observed in Sgsh-deficient mice.
- 1 cited this week
Most human genes produce multiple protein isoforms through alternative splicing, with recent evidence showing these isoforms are widespread, biochemically distinct, and linked to disease.
- 1 cited this week
Cumulative transcription factor binding and p300 activity determine enhancer activation frequency in eukaryotic cells.
- 1 cited this week
Topics that moved
- Single-cell and spatial transcriptomics · 6 papers
- Neuroinflammation and Neurodegeneration Mechanisms · 5 papers
- Cancer Immunotherapy and Biomarkers · 5 papers
- Gut microbiota and health · 5 papers
- Cancer Genomics and Diagnostics · 4 papers
- Bacteriophages and microbial interactions · 4 papers
- CAR-T cell therapy research · 3 papers
- Lung Cancer Treatments and Mutations · 3 papers
- Liver Disease Diagnosis and Treatment · 3 papers
- Dementia and Cognitive Impairment Research · 3 papers
- Inflammatory Bowel Disease · 3 papers
- Influenza Virus Research Studies · 3 papers
- Tuberculosis Research and Epidemiology · 3 papers
- All topics →
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Journals this month
- bioRxiv6244
- medRxiv1789
- PNAS447
- Sci Adv354
- JAMA268
- Environ Res246
- BMJ196
- Nat Commun173
- Environ Pollution167
- Nature151
- Applied & Environ Microbio145
- Science141
- Lancet128
- Cell Rep127
- NEJM119
- Plant Cell Environ118
- J Exp Bot107
- mBio107
Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3