Most human genes produce multiple protein isoforms through alternative splicing, with recent evidence showing these isoforms are widespread, biochemically distinct, and linked to disease.
- 1 cited this week
Trends in Genetics
Elsevier BV · Genomics & Bioinformatics · ISSN 0168-9525, 1362-4555
- Impact (2-yr)
- 7.4
- h-index
- 330
- Open access
- 20%
- Works
- 7.2K
- Papers this month
- 19
Track Trends Genet in JClubFree on iPhone and Android · in the app, the list is My Journals
Rebuilt
Moved this week
Latest in Trends Genet
Newest first · last 60 days
PEAK variants are associated with more severe clinical phenotypes than heterozygous null alleles in the same gene.
Design foresight and model humility are essential for accurate transcriptome-first omics inference, emphasizing the importance of question-driven assay selection and honest data interpretation.
Changes in pre-mRNA 3'-end processing and transcription termination can occur in opposing directions, revealing a complex relationship at gene ends.
GlycoRNAs, a novel class of small noncoding RNAs covalently modified with N-glycans, reside on the cell surface and reshape RNA regulatory understanding.
- Open access
Genetic suppressors may provide new therapeutic targets for Mendelian diseases by counteracting disease-causing mutations.
- Open access
Marsupial genome editing has only been achieved in Monodelphis domestica, despite the availability of high-quality genomes for other species.
Mitochondrial DNA acts as a primary evolutionary engine driving nuclear coadaptation, expanding mitonuclear haplotype pools within species.
Genomic research indicates that fungi previously thought to be asexual actually exhibit a continuum of sexual activity, challenging the myth of complete asexuality.
Genome architecture can evolve rapidly in cancer cells due to mutations and epigenetic changes, highlighting dynamic micro-scale structural shifts.
DNA double-strand breaks within actively transcribed loci trigger rapid transcription repression through chromatin remodeling and RNAPII modifications to coordinate repair.
Supercentenarians harbor expanded, nonexhausted CD4+ cytotoxic T lymphocytes that retain potent cytotoxicity and functional plasticity.
Position-aware phylogenomics reveals evolutionary signals inaccessible to traditional 'bag-of-genes' models, advancing understanding of genome evolution.
Reading RNA turnover alongside abundance reveals a small, fast-decaying subpopulation of lncRNAs that may contain regulators, which is missed by steady-state RNA sequencing.
Therapeutic germline gene editing could shift medicine from treatment to prevention by correcting disease mutations at the embryo stage.
Transposable elements have a mutation rate of 1.6 × 10^-3 gains per copy per generation, which is an order of magnitude higher than the loss rate of 1.9 × 10^-4.
Six lessons for fostering constructive dialogue and mutual learning between scientific and spiritual communities in discussions about CRISPR and genetic technologies.
Primary care professionals need education, workflow support, and genetics access to deliver genomics-informed healthcare effectively.
Loss-of-function variants in FNIP1 are linked to reduced cardiometabolic disease risk in over 1 million exomes, highlighting FNIP1 as a metabolic brake.
DNA methylation offers a unifying framework to understand and differentiate complex chronic conditions like ME/CFS, LC, FM, and hEDS.
Chromosome-scale genome engineering is advancing with tools for transfer, elimination, and transplantation in higher eukaryotes, enabling manipulation of megabase regions and whole chromosomes.
Africa contains more genetic variation than the rest of the world combined, yet only about 1% of genomes in major databases are from individuals of African ancestry.
Condensins, topoisomerase IIα, and physical forces collectively drive mitotic chromosome assembly through dynamic looping and entanglement processes.
Hologenomic interactions expand heritable variation and promote phenotypic complexity, influencing evolutionary trajectories in the holobiont system.
Circular RNAs (circRNAs) are highly stable, covalently closed RNAs that actively regulate the stability of other RNA molecules, including mRNAs and microRNAs.
Gene regulatory network architecture influences evolvability, with recent advances enabling direct empirical testing of theoretical principles.
Genotype-phenotype relationships in neurodevelopmental disorders are highly complex, with diverse clinical outcomes observed even among individuals with the same risk gene variants.
Generative genomic AI models pose significant safety risks, including data quality issues, biases, and dual-use concerns, especially in critical fields like medicine and pathogen engineering.
- Open access
Single-cell omics reveals key transcription factors that determine cell fate with diverse computational approaches.
Giant extrachromosomal elements over 1 Mb in size have been discovered in prokaryotes, revealing a new class of microbial mobile genetic elements.
The fungal RIP hypermutator mechanism, targeting transposable elements, shares deep evolutionary roots across eukaryotes, highlighting conserved defense strategies.
- Open access
Track Trends Genet in JClub
Browse JClub
Journals this month
- bioRxiv6131
- medRxiv1703
- PNAS447
- Sci Adv354
- JAMA262
- Environ Res230
- BMJ182
- Environ Pollution165
- Nat Commun161
- Science141
- Nature138
- Lancet128
- Cell Rep120
- NEJM119
- mBio107
- Plant Cell Environ107
- Curr Biol106
- J Exp Bot106
Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3