Molecular phenotypes and spatial archetypes reveal distinct CAF identities linked to tissue context, advancing precision targeting in cancer therapy.
- 3 cited this week
- Open access
Cancer Cell
Cell Press · Oncology · ISSN 1535-6108, 1878-3686
- Impact (2-yr)
- 35.4
- h-index
- 485
- Open access
- 95%
- Works
- 4.3K
- Papers this month
- 27
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Neural signaling's role in tumor progression varies with context, influenced by tumor kinetics, tissue structure, and immune interactions, highlighting a complex, adaptable system.
- 1 cited this week
GABA upregulation in TLS-positive tumors is linked to resistance to immune checkpoint inhibitors in ccRCC and STS patients.
- 6 cites
Spatial multi-omics reveals that liver micrometastases in colorectal cancer originate early and exhibit dormancy, with a six-gene signature linked to disease recurrence and therapy resistance.
- Open access
- 5 cites
Firmonertinib shows promising systemic and intracranial efficacy in preclinical models of PACC-mutant NSCLC, supporting its further clinical development.
Microbiota-driven stem-like lymphoid niche with CD70+ ILC2s sustains progenitor exhausted T cells, redefining TLS-associated antitumor immunity.
A premalignant chromatin state linked to gastric cancer involves a pseudo-gastric subtype that exploits acid secretion to evade immune responses.
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Firmonertinib achieves objective response rates of 43% and 68% in first-line treatment of EGFR PACC-mutant NSCLC, with median progression-free survival up to 16 months.
Firmonertinib shows promising systemic and intracranial efficacy in preclinical models of PACC-mutant NSCLC, supporting its further clinical development.
Immune checkpoint inhibitors show time-of-day-dependent effects in pre-clinical models and earlier treatment timing is linked to better outcomes in retrospective trials.
Proteo-genomics analysis of 139,818 cancer patient genomes reveals mutation accumulation in key functional regions across 173 genes and 18 tumor types.
Seven FDA-approved CAR T cell products for 15 indications demonstrate the therapy's established effectiveness in cancer treatment.
Combining HRS-4642 with adebrelimab yields a 43% response rate in previously treated metastatic pancreatic cancer without gastrointestinal toxicity.
Microbiota-driven stem-like lymphoid niche with CD70+ ILC2s sustains progenitor exhausted T cells, redefining TLS-associated antitumor immunity.
Chemotherapy with carboplatin plus paclitaxel or cyclophosphamide enhances vaccine efficacy by expanding stem-like TCF1(+)CD8(+) T cells in cancer models and patients.
Brain-seeding cancer cells exploit an MXD4-dependent proliferative pause that may be targeted to eradicate micrometastases before relapse.
Patient-derived organoids (PDOs) effectively preserve human tumor features, enabling functional evaluation of CAR T cell targets and resistance mechanisms in solid tumors.
High γδ T cell infiltration in small cell lung cancer predicts improved response to anti-PD-L1 immunotherapy.
- Open access
Mapping significantly mutated regions to protein domains and structural features creates a proteo-genomics framework for interpreting cancer mutations beyond genes and hotspots.
Myeloid-specific Tet2 deletion generates myeloid-derived activating cells that enhance radiotherapy and suppress metastasis in lung cancer models.
Ensemble learning with five pretrained pathology models improves tumor subtyping, biomarker, and therapy-response prediction in computational pathology.
Ensemble learning of five pathology foundation models improves performance across multiple oncology tasks using 53,699 WSIs.
UniCure accurately predicts personalized cancer drug responses across diverse cell and tissue contexts using 1.9 million transcriptomic profiles.
A transient MXD4-dependent proliferative pause enables survival of brain micrometastases, with disruption reducing progression to macrometastases in models and patients.
Tumor-macrophage niches in bladder cancer promote chemoresistance, with PARP14 inhibition transforming these niches into cisplatin-sensitive environments.
Intratumoral Bacillus cereus promotes stem-like lymphoid niches that enhance PD-1/PD-L1 blockade response in hepatocellular carcinoma.
γδ T cells activated by a BiTE can target small cell lung cancer independently of MHC-I expression, overcoming limitations of CD8+ T cell responses.
Anti-PD-1 sensitivity in diverse mouse models is more closely linked to the diet-microbiome-metabolite ecosystem than to obesity-associated metabolic dysfunction.
A chemotherapy-free combination of HRS-4642 and adebrelimab shows a 43.2% objective response rate in previously treated metastatic KRAS G12D-mutant pancreatic ductal adenocarcinoma.
Single-cell and spatial transcriptomics reveal that mesenchymal neuroblastoma cells are linked to worse survival outcomes in patients.
A premalignant chromatin state linked to gastric cancer involves a pseudo-gastric subtype that exploits acid secretion to evade immune responses.
A pseudo-gastric epigenomic subtype in gastric cancer is intrinsically drug resistant and characterized by an acid-driven immunotherapy resistance linked to FOSL2 activity.
EGFR-targeting antibody-drug conjugate SYS6010 shows potential in advanced solid tumors, marking a shift from kinase inhibition to antigen-guided drug delivery in non-small cell lung cancer.
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Journals this month
- bioRxiv6244
- medRxiv1789
- PNAS447
- Sci Adv354
- JAMA268
- Environ Res246
- BMJ196
- Nat Commun173
- Environ Pollution167
- Nature151
- Applied & Environ Microbio145
- Science141
- Lancet128
- Cell Rep127
- NEJM119
- Plant Cell Environ118
- J Exp Bot107
- mBio107
Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3