Cumulative transcription factor binding and p300 activity determine enhancer activation frequency in eukaryotic cells.
- 1 cited this week
Nature Genetics
Nature Portfolio · Genomics & Bioinformatics · ISSN 1061-4036, 1546-1718
- Impact (2-yr)
- 19.3
- h-index
- 776
- Open access
- 41%
- Works
- 11.9K
- Papers this month
- 51
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Nanoparticle-enriched mass spectrometry reveals over 1,200 novel plasma protein genetic associations in British South Asians, advancing understanding of disease mechanisms.
- 5 cites
A disease-associated microglial subtype with elevated GPNMB expands with Alzheimer's pathology and depends on TREM2 for neuroprotection.
- Open access
- 22 cites
Manc-COJO enhances detection of independent associations in multiancestry GWAS, outperforming GCTA-COJO with over 120-fold faster processing and improved accuracy.
- Open access
- 1 cites
GISMO and GISMO-mis, two mammalian constraint metrics, strongly correlate with human gene essentiality and identify critical genes missed by existing methods, especially short genes.
- Open access
Latest in Nat Genet
Newest first · last 60 days
Monoallelic variants in inborn errors of immunity often perturb signaling pathways rather than abolish gene function, highlighting complex system-level influences on disease expression.
Manc-COJO enhances detection of independent associations in multiancestry GWAS, outperforming GCTA-COJO with over 120-fold faster processing and improved accuracy.
- Open access
- 1 cites
GISMO and GISMO-mis, two mammalian constraint metrics, strongly correlate with human gene essentiality and identify critical genes missed by existing methods, especially short genes.
- Open access
H2Aub-dependent H3K27me3 deposition establishes early Polycomb repression in human embryos, with H2Aub emerging by the two-cell stage and affecting gene regulation.
Clonal heterogeneity in human pancreatic ductal adenocarcinoma includes multiple genetically distinct neoplastic clones within individual tumors, with MYC amplification linked to tumor progression.
Micronuclear ecDNA formation under replication stress reduces tumor cell fitness and is linked to improved survival in MYCN-amplified neuroblastoma patients.
- Open access
Imputation of fluid intelligence scores increases genetic associations from 390 to 550 and identifies 26 neurodevelopmental genes, including 8 novel candidates.
- Open access
Reactivating the silenced embryonic ζ-globin gene in mice and human cells can produce therapeutic levels of α-like globin, rescuing severe α-thalassemia conditions.
- Open access
Updated guidelines for returning secondary genomic findings in observational cohort studies emphasize ethical, equitable, and scalable practices.
RovHer prioritizes rare missense variants, explaining 16.1% of total RV heritability in UK Biobank traits, a tenfold increase over alternative methods.
- Open access
Evolutionary increases in CCNB1IP1 expression are linked to cortical size and folding in primates, with knock-in experiments inducing cortical folding in mice.
ArchMap enables accessible, no-code reference-based analysis of single-cell datasets, supporting over 100 integrated reference atlases and expanding with the Human Cell Atlas.
- Open access
Rare CNVs are significantly associated with schizophrenia in East Asian populations, with 14 loci identified, including 8 novel genome-wide significant loci.
OLR1(+) scar-associated macrophages are spatially enriched in fibrotic liver tissue and linked to increased fibrosis in chronic liver disease.
Single-allele MCCv reveals a neo-CTCF motif creating a gain-of-function mechanism linked to autoimmunity in CD4+ T cells.
Germline HRD reduces clonal hematopoiesis expansion during platinum and PARP inhibitor treatment in patients with TP53-mutant CH.
Cell-type-specific chromatin accessibility in the human intestine reveals that Crohn's disease heritability is primarily enriched in T cells and neutrophils, with 30 variants located within cCREs.
Crop legacy effects on soil properties are heritable traits that can be targeted in breeding to promote sustainable farming systems.
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3