China approves satricabtagene autoleucel, the first CAR T-cell therapy for solid tumors, for claudin 18.2-positive, HER2-negative gastric or gastro-esophageal junction cancer.
- 1 cited this week
- In the news
Cancer Discovery
American Association for Cancer Research · Oncology · ISSN 2159-8274, 2159-8290
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- 31%
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- Papers this month
- 48
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In vivo CAR T-cell therapy KLN-1010 achieved a 100% overall response rate in all 18 multiple myeloma patients in a phase I trial.
- In the news
Six months of apalutamide combined with ADT increases 5-year metastasis-free survival to 78.2% in high-risk localized prostate cancer patients.
- In the news
A 14-protein blood test predicts lung cancer risk more than 5 years before detection, including in never-smokers outside current screening criteria.
- In the news
The FDA's pilot program includes two proof-of-concept clinical trials reporting endpoints and data signals in real time, involving AstraZeneca and Amgen.
- In the news
RNA-triggered chromatin shredding using Cas12a2 can selectively eliminate tumor cells with mutations in TP53, MYC, and other difficult-to-drug cancer genes in mouse models.
- In the news
All-oral decitabine-cedazuridine and venetoclax regimen shows promise for AML patients, with potential improvements in treatment options.
- In the news
AJ1-11095, a type II JAK2 inhibitor, produced impressive clinical responses in a phase I study for myelofibrosis, indicating potential advantages over existing inhibitors.
- In the news
DNA-based GNOS-PV01 and peptide-based NeoVax vaccines show promise for glioblastoma patients, with GNOS-PV01 effective against the challenging MGMT-unmethylated subtype.
- In the news
Blood Cancer United secures remaining luveltamab tazevibulin supply to support compassionate use for children with a rare AML.
- In the news
Latest in Cancer Discov
Newest first · last 60 days
BioNTech's HPV16 mRNA vaccine BNT113 does not significantly delay head and neck cancer progression in a phase II/III trial, exemplifying challenges for shared-antigen cancer vaccines.
Epigenetically primed tumor cell states marked by H3K4me1 predict chemoresistance in high-grade serous ovarian cancer.
A single post-lactation dose of cabergoline reduces postpartum mammary cancer incidence by approximately 69% in mice and is linked to lower breast cancer risk in women.
ARPA-H's SURPASS program aims to create faster, more cost-effective clinical trials with fewer participants, targeting improvements in trial design and regulation.
Over 95% of breast cancer patients harbor metastasis-specific mutations in at least 10 pathways, with mutability-dependent mutations accumulating after dissemination to influence metastasis.
Germline pathogenic variants are most prevalent in early-onset cancer patients, with 18.4% in early-onset tumors compared to 12.3% in late-onset tumors, across 32 tumor types.
Optogenetics, a Nobel-winning technology, is increasingly used by cancer researchers to study tumor responses to nervous system signals.
Tumor-derived ADAMTSL4 is linked to cancer cachexia by activating TGFβ1 and promoting multiorgan wasting and fibrosis in preclinical models and patients.
MSS colorectal cancers evade immune responses through intrinsic secretome-driven mechanisms, despite identical antigen presentation to MSI tumors.
- Open access
A spatial atlas of muscle-invasive bladder cancer shows a continuous luminal-to-basal axis linked to chromosomal instability and transcriptional plasticity in individual tumors.
- Open access
A senescent-like neutrophil subset marked by BHLHE40 is enriched in colorectal cancer liver metastasis and linked to poor prognosis.
MutationProjector, a pre-trained genomic model, predicts therapeutic resistance and sensitivity across multiple cancer types with performance matching or exceeding state-of-the-art methods.
- Open access
Dietary fatty acid composition distinctly influences pancreatic tumor initiation, with monounsaturated fats promoting and polyunsaturated fats suppressing PDAC in mice.
Glucose deprivation in colorectal cancer liver metastases induces neutrophil senescence, with TAN1 promoting angiogenesis and excluding CD8+ T cells to support tumor growth.
ADAMTSL4 from tumors promotes tissue wasting in cancer cachexia by activating latent TGFβ1, revealing a new post-secretory control mechanism.
[18F]RCCB6 PET/CT achieves 94.2% sensitivity in detecting metastases in clear-cell renal cell carcinoma, outperforming [18F]FDG PET/CT and conventional imaging.
Genomic context and treatment exposure define distinct glioblastoma recurrence trajectories, with TP53 mutations linked to early recurrence and resistance.
LPL-positive endothelial cells promote intratumoral CD8+ T-cell homing and liver metastasis regression by enhancing antigen presentation.
- Open access
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Journals this month
- bioRxiv6244
- medRxiv1789
- PNAS447
- Sci Adv354
- JAMA268
- Environ Res246
- BMJ196
- Nat Commun173
- Environ Pollution167
- Nature151
- Applied & Environ Microbio145
- Science141
- Lancet128
- Cell Rep127
- NEJM119
- Plant Cell Environ118
- J Exp Bot107
- mBio107
Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3