State predicts cellular perturbation effects across diverse contexts with over 30% improved discrimination on large datasets.
- 6 cited this week
Cell
Cell Press · Cell & Molecular Biology · ISSN 0092-8674, 1097-4172
- Impact (2-yr)
- 41.6
- h-index
- 1.2K
- Open access
- 66%
- Works
- 27K
- Papers this month
- 82
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A telomere-to-telomere human genome benchmark achieves 99.4% accuracy, adding 701.4 Mb of previously missing autosomal and sex chromosome sequences.
- 5 cited this week
CD8+ T cell immunity enhances tumor cell susceptibility to cuproptosis, improving the effectiveness of inducers in overcoming immunotherapy resistance in preclinical models.
- 4 cited this week
- Open access
AI model "Path2Space" predicts spatial gene expression from histopathology slides, accurately inferring thousands of genes and outperforming 21 established methods in breast cancer.
- 3 cited this week
- Open access
Complete Drosophila male CNS connectome reveals 138 dimorphic neuron types, highlighting sex-specific neural circuit differences at synaptic resolution.
- 3 cited this week
MBS1 condensates in rice chloroplasts provide high-light tolerance by acting as a sunscreening mechanism, with overexpression increasing yield under stress conditions.
- 1 cited this week
Multimodal aging clocks accurately quantify human biological age and reveal coagulation factors as key drivers of multi-organ senescence.
- 2 cited this week
MSA Pairformer predicts protein-protein interface contacts nearly 3 times more accurately than existing methods, despite training only on individual chains.
- Open access
- 2 cites
Comparative analysis reveals 8,619 mitochondrial proteins across eight species, uncovering conserved families and potential drug targets in eukaryotic pathogens.
- 8 cites
Rare k-mers in centromeric regions define distinct haplogroups with structural features linked to human diversity and disease susceptibility.
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Extracellular L-carnitine activates the pyrin inflammasome via OCTN2 in macrophages, linking skeletal muscle injury and red meat consumption to inflammation.
IsoUDCA, a bile acid linked to a bacterial consortium enriched by estrogen, may mediate female hepatoprotection in chronic liver disease.
A reversible photoswitchable morphinan agonist enables optical control of MOR signaling with reduced side effects in mice.
Resident tissue macrophages transfer selenium transporter Selenop to EMT-high tumor cells, promoting ferroptosis resistance and tumor progression in pancreatic ductal adenocarcinoma.
Cellular self-organization constrains ferroptosis propagation through spatial patterning and polarized lipid organization, limiting unbounded oxidative cell death waves.
Osteopontin in maternal milk influences the neonatal microbiome to promote dendritic cell development and protect against severe respiratory infection.
A near-telomere-to-telomere assembly reveals that 16% of somatic variants in melanoma occur in sequences absent from the reference genome, highlighting previously inaccessible genomic regions.
The SMaHT Network provides the first body-wide map of somatic mosaicism, establishing a baseline of "normal" human somatic variation.
Two distinct human dispersals reached Fiji at least centuries earlier than previously thought, with Papuan-related expansion progressing more slowly than Lapita-associated groups.
Ratiometric transcriptional activation converts protein degradation into highly sensitive gene expression signals in live cells, enabling detection of multiple protein downregulation events.
Embedded rNMPs in the human genome are linked to DNA supercoiling regulation and transcription, with over 1 million rNMPs mapped per genome.
Glycolytic and pentose phosphate pathway activity increase during late neurogenesis in the early human cortex, influencing cell fate transitions.
Milk-derived osteopontin (OPN) deficiency in neonatal mice increases susceptibility to severe respiratory infections by disrupting dendritic cell hematopoiesis.
Retrotransposons upstream of V H genes are co-opted to promote antibody diversification through L1-driven somatic hypermutation in B cells.
Agentic AI systems like Co-Scientist, Robin, and Biomni can generate hypotheses, design experiments, analyze data, and refine reasoning through feedback, advancing autonomous scientific reasoning.
RNA editing in Doryteuthis pealeii confirms 7,997 recoded sites at the protein level, reshaping the proteome by affecting stability, localization, modifications, and activity.
Reactive oxygen species (ROS)-associated stress responses in both host cells and rhizobia are linked to symbiotic nitrogen fixation in Medicago nodules.
Loss of GIMAP6 in mice causes inflammatory vasculopathy and accelerated atherosclerosis without hyperlipidemia, leading to early cardiac ischemia and death.
Estrogen-driven activation of STING signaling promotes neutrophil extracellular trap formation, causing female-biased resistance to ADC therapy in pancreatic cancer models.
Switching from IRF2 to IRF1 occupancy at ISG sites enhances innate immune gene activation during inflammation in mice.
Mitochondria-targeted tetraoxanes WMK-1/2 induce ferroptosis independently of GPX4, suppressing tumors in multiple cancer models.
Loss of Zfp219 enhances antitumor immunity in aged mice by inducing epigenetic reprogramming and increasing cytotoxic molecule expression, leading to tumor clearance.
An Oryza-specific orphan gene, ROAD1, confers up to 34.75% higher grain yield under drought in rice and enhances drought tolerance across multiple plant species.
Somatic chromatin epimutations in human cells create mitotically stable, non-genetically deterministic alterations, with the HLA locus showing the highest haplotype-selective accessibility.
Deep subcortical structures like the hypothalamus and brain stem harbor the greatest neuronal cell type diversity in the mammalian brain, not the cortex or cerebellum.
Arabidopsis employs pH-specific coumarins and bacterial pathways for iron acquisition, with bacterial genes prevalent in root microbiota and likely evolved before land plants.
A phenome-wide association study of 1.6 million structural variants in 467,152 UK Biobank participants identified 28,184 links to human health outcomes, revealing the significant impact of SVs.
Using donor-specific and pangenome-inferred diploid assemblies improves somatic mutation calling, extending catalogs to challenging genomic regions in human tissues.
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- bioRxiv6244
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- PNAS447
- Sci Adv354
- JAMA268
- Environ Res246
- BMJ196
- Nat Commun173
- Environ Pollution167
- Nature151
- Applied & Environ Microbio145
- Science141
- Lancet128
- Cell Rep127
- NEJM119
- Plant Cell Environ118
- J Exp Bot107
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3