Lysosomal dysfunction causes microglia-specific epigenetic and transcriptional changes linked to neurodegenerative diseases, with a significant impact observed in Sgsh-deficient mice.
- 1 cited this week
Immunity
Cell Press · Immunology & Inflammation · ISSN 1074-7613, 1097-4180
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Progranulin deficiency causes lysosomal dysfunction that triggers maladaptive myeloid cell states via MITF/TFE transcription factors, impacting neurodegeneration.
- 1 cited this week
TCR origin and antigen recognition shape peripheral Treg cell differentiation, with TCRs from Treg cells more effectively inducing tolerance across diverse antigens.
- 1 cites
Activation of auricular vagus nerve reflex reduces allergic airway inflammation by 50% in mice through sensory neuron stimulation.
- 3 cites
BACH1 acts as a pioneer repressor, priming chromatin and regulating macrophage plasticity with 3D architecture constraints, crucial for tissue adaptation and inflammation responses.
- Open access
- 3 cites
CCR7(+) activated dendritic cells are crucial for both spontaneous and therapy-induced anti-tumor immune responses, with their ablation impairing tumor control.
- 2 cites
Latest in Immunity
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Macrophage identity is best described as a modular combination of gene programs rather than fixed subsets or binary states.
LDHA-dependent redox control of mRNA translation directs monocyte fate commitment to NOS2+ macrophages in vivo.
CD163 high red pulp macrophages, originating from yolk sac progenitors, are rapidly depleted during blood-stage malaria and are essential for maintaining splenic architecture.
A second round of nociceptor activation within 3-12 hours licenses an IL-23-centered inflammatory program via CGRPα in skin inflammation.
Distant lymph nodes can compensate for resected tumor-draining lymph nodes to sustain anti-cancer immunity during immunotherapy.
Cancers evade T cell detection by avoiding presentation of p53 neoantigens through multiple mechanisms, including mutation localization and HLA allele loss.
Intestinal inflammation leaves a durable extracellular matrix imprint that influences stem-cell fate and promotes persistent immune activation.
Viral deISGylation broadly relieves ISG15-mediated restriction of key metabolic pathways to promote viral replication.
Immune checkpoint blockade has significantly transformed cancer treatment and has led to an exponential growth in immunotherapy strategies across various diseases.
AlphaFold3 structural predictions accurately identify reactive TCR-pMHC pairs without task-specific training, challenging previous reactivity estimates in immunology.
Persistent pathological ECM reprogramming after gut inflammation directs intestinal stem cells toward a pro-inflammatory, wound-associated epithelial state.
Different antigen-presenting cells dictate T cell fates in response to dietary versus gut epithelial self-antigen, with distinct APC dependencies linked to immune outcomes.
Two rounds of nociceptor activation are necessary to initiate maximal type-17 inflammation in the skin, involving dendritic cell aggregation and neuropeptide signaling.
Loss of SARS-CoV-2 deISGylating activity enhances innate immunity, reduces viral replication, and promotes clearance in human cells and mice.
BTNL3-BTNL8 forms an antigen-independent tetramer that clamps Vγ4Vδ1 TCRs, revealing a unique activation mechanism in human γδ T cells.
CD40 engagement and cytokines induce lipid droplet accumulation and antigen presentation in astrocytes, enhancing pathogenic CD4+ T cell responses during experimental autoimmune encephalomyelitis.
ILC2s in the dura activate myelin-reactive T cells via MHC class II, promoting neuroinflammation during EAE.
Chemical compounds can efficiently induce stable IL-10 production in B cells, enabling their regulatory function to restrain neuroinflammation.
Nasal immunity involves coordinated epithelial and immune cell responses that may limit viral spread and transmission, with insights gained from advanced single-cell technologies.
N6-induced regulatory B cells expressing IL-10 at over 95% frequency reverse CNS autoimmunity by targeting myeloid cells in experimental models.
Double-negative 2 (DN2) atypical memory B cells are identified as key precursors of autoantibody-producing cells during SARS-CoV-2 infection, especially in autoAb-high individuals.
Distinct barriers to processing, presentation, and recognition of mutant p53 neoantigens limit CD8(+) T cell responses in cancer.
CXCR6(+) CD4(+) tissue-resident memory T cells form perivascular clusters with dendritic cells that drive relapse in allergic dermatitis.
The GZMK(+)/GZMB(+) Tem cell ratio predicts health trajectories and distinguishes healthy from pathology-associated immune aging in 2,609 individuals.
Inhibiting viral-induced lymphatic remodeling in skin and lymph nodes causes germinal center expansion but reduces protective antibody responses in mammals.
Microglia-driven ECM disruption linked to neuronal dysfunction, motor impairments, and sedation in alcohol abuse models, with MyD88 deletion offering protection.
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- bioRxiv6244
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- PNAS447
- Sci Adv354
- JAMA268
- Environ Res246
- BMJ196
- Nat Commun173
- Environ Pollution167
- Nature151
- Applied & Environ Microbio145
- Science141
- Lancet128
- Cell Rep127
- NEJM119
- Plant Cell Environ118
- J Exp Bot107
- mBio107
Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3