Global pain trajectories across the lifespan were established from over 6.1 million individuals in 118 countries, revealing higher late-life pain prevalence in low-HDI nations.
- 1 cited this week
- 1 on Bluesky
- Open access
Nature Medicine
Nature Portfolio · General Science & Medicine · ISSN 1078-8956, 1546-170X
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- 763
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- 92
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Genetic analysis of 2.5 million individuals reveals fibromyalgia as a central nervous system disorder with 26 risk loci, including a key variant in HTT.
- 8 cites
Imaging and serum biomarkers, including MRE and Agile scores, accurately diagnose cirrhosis with AUCs exceeding 0.87 in MASLD patients.
- 8 cites
Over 59% of pancreatic cancer patients treated with daraxonrasib develop resistance through RAS pathway alterations, including KRAS amplification and RTK upregulation.
- Open access
- 8 cites
Personalized neoantigen-targeting cancer vaccines showed safety and immune activity in high-grade epithelial ovarian cancer patients, with 75% of recurrent patients vaccinated.
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Genomic, transcriptomic, and epigenomic features predict measurable residual disease in newly diagnosed multiple myeloma treated with quadruplet therapy, with an AUC of 0.77.
D2C7-ATC therapy is linked to prolonged survival in a subset of patients with IDHwt recurrent glioblastoma, with a median overall survival of 17.38 months in certain cases.
Digital delivery of GLP-1RA therapy in women results in a mean weight loss of 16.1 kg, or 15.5% of baseline weight, in a real-world UK cohort.
- Open access
Talazoparib plus enzalutamide achieved a 73% PSA <0.2 ng/ml response rate at 12 months in high-volume metastatic hormone-naive prostate cancer, exceeding efficacy thresholds.
- Open access
Personalized neoantigen-targeting cancer vaccines showed safety and immune activity in high-grade epithelial ovarian cancer patients, with 75% of recurrent patients vaccinated.
A device platform using AI and patient feedback improves seizure detection precision in 13 epilepsy patients, reducing false alarms without expert intervention.
Longitudinal clinicogenomic data from over 52,000 cancer patients reveal cachectic weight loss episodes cluster near disease progression and are linked to worse outcomes across cancer types.
- Open access
Only 12.2% of 3,967 clinical prediction model articles include code-sharing statements, with significant variation across journals and countries.
- Open access
In vivo BCMA CAR-T therapy achieved a 100% objective response rate with durable remission in one patient for up to 15 months in relapsed/refractory multiple myeloma.
Global pain trajectories across the lifespan were established from over 6.1 million individuals in 118 countries, revealing higher late-life pain prevalence in low-HDI nations.
- 1 cited this week
- 1 on Bluesky
- Open access
Safiglipron at all tested doses is non-inferior to dapagliflozin in reducing HbA1c in adults with type 2 diabetes over 32 weeks.
- Open access
Urine cfRNA profiling using uRARE-seq detects localized bladder cancer with 95% sensitivity and 90% specificity, outperforming urine tumor DNA analysis.
Dysregulated adult hippocampal neurogenesis in the hippocampal subgranular zone is linked to major depressive disorder, showing a stalled neurogenic process associated with stress and immune signaling.
Semaglutide reduces vascular resistance and prevents fibrosis in kidneys of people with type 2 diabetes and chronic kidney disease, as shown by secondary outcomes.
- Open access
COVID-19 vaccination around ICI therapy is linked to modest, short-term reductions in all-cause mortality among cancer patients, with no long-term survival benefit observed.
A large language model-based clinical decision support system in the emergency department showed declining clinician engagement and no significant impact on patient length of stay over 4 weeks.
The multi-cancer early detection test in the NHS-Galleri trial detected primary cancers in 0.40% to 0.60% of participants across three screening rounds.
- Open access
- 1 cites
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- Nature151
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- Cell Rep127
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3