Semaglutide improves liver health in mice with MASH through intrahepatic sinusoidal endothelial GLP-1 receptors, independent of weight loss, with a substantial effect on fibrosis and immune remodeling.
- 1 cited this week
Liver Disease Diagnosis and Treatment
Moving in Cell Metabolism, Gut and Nature Medicine.
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- 49
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Imaging and serum biomarkers, including MRE and Agile scores, accurately diagnose cirrhosis with AUCs exceeding 0.87 in MASLD patients.
- 8 cites
Latest in Liver Disease Diagnosis and Treatment
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Hepatic and serum metabolite levels show weak correlation, with liver metabolites more strongly associated with steatosis and inflammation than serum metabolites in severe obesity.
Nucleos(t)ide analogues therapy significantly reduces risks of cirrhosis and hepatocellular carcinoma in specific chronic hepatitis B subgroups outside 2025 EASL criteria, especially in HBeAg-positive patients with high replicative or impending phase transition phenotypes.
- Open access
- 6 cites
Hepatic glutamine depletion is linked with increased CD4+ T cell inflammation and worsened liver damage in MASLD patients and mouse models.
- Open access
DD01 achieved a 76% rate of at least 30% liver fat reduction at 12 weeks in adults with MASLD or MASH, significantly surpassing the 12% in the placebo group.
Primary liver cancer incidence and mortality increased by over 55% globally from 2000 to 2023, reversing earlier declines around 2020.
- Open access
Liver cancer surveillance lacks randomized trial evidence, with most positive results being false positives in low-prevalence populations, limiting support beyond hepatology.
- Open access
- 1 cites
VGLL4 promotes MAFLD progression by enhancing PDK4 transcription, with hepatocyte-specific overexpression inducing steatosis and knockout protecting mice from metabolic dysfunction.
- Open access
Missingness-aware machine learning models using routine lab data achieve significantly higher discrimination of cirrhosis among hepatitis patients, with AUC up to 0.841.
- Open access
Multidisciplinary heart-liver co-management improves detection and treatment of MASLD, addressing a critical gap in cardiometabolic care with potential to reduce mortality.
Pre-pregnancy parental obesity significantly increases the risk of adult offspring MASLD, with a 3.73-fold higher odds when both parents are overweight or obese.
- 3 cites
Metabolic dysfunction-associated steatotic liver disease (MASLD) significantly increases colorectal cancer (CRC) risk, especially with greater disease severity and metabolic burden, according to expert consensus.
- 3 cites
Cardiolipin deficiency in mitochondria impairs electron transport chain function and causes steatohepatitis in mice and humans.
- Open access
- 3 cites
Abbreviated MRI protocols and blood-based biomarkers show promise for improving hepatocellular carcinoma surveillance accuracy and patient adherence.
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3