Switching to camizestrant at ESR1 mutation emergence during first-line therapy significantly extends progression-free survival in hormone receptor-positive advanced breast cancer, with a median of 16.8 months.
- 2 cited this week
The Lancet Oncology
Elsevier BV · Clinical Medicine · ISSN 1470-2045, 1474-5488
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Access to cancer genomics and precision oncology remains profoundly unequal across and within countries, leaving millions without guideline-indicated interventions annually.
- 10 cites
Latest in Lancet Oncol
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Digital breast tomosynthesis plus s2D mammography shows a 14.2 per 10,000 invasive interval cancer rate, compared to 18.6 per 10,000 with digital mammography in women aged 50-70.
Neoadjuvant niraparib achieved an 80% R0 resection rate in HRD-positive advanced ovarian cancer patients initially unsuitable for primary debulking surgery.
Five-year follow-up shows that the OPTIMUM trial's intensified therapy significantly prolongs progression-free and overall survival in high-risk multiple myeloma patients compared to external controls.
The CPI2 prognostic model for metastatic clear cell renal cell carcinoma achieved a discriminative accuracy of 0.72 at 36 months, surpassing the IMDC model in external validation.
Higher microbial diversity and enrichment of immunostimulatory pathways in the gut microbiome are linked to improved immune checkpoint inhibitor response and survival in melanoma, non-small-cell lung cancer, and renal cell carcinoma.
Infections are linked to 2.3 million new cancer cases globally in 2024, representing 12% of all new cancer diagnoses worldwide.
The STAMINA lifestyle intervention significantly improves quality of life and reduces fatigue in men with prostate cancer on ADT, with FACT-P scores increasing by 4.5 points.
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Topics moving, week to 22 Oct 2026
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