Cell death mechanisms and regulation
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Latest in Cell death mechanisms and regulation
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Bruce inhibits wing tissue growth in Drosophila by regulating autophagy-dependent activation of non-lethal caspase Dcp-1.
- Open access
Electrostatic attraction alone can compact and sequester fragmented chromatin during apoptosis, preventing DNA release into extracellular vesicles.
- Open access
F-actin up-regulation in Pardosa pseudoannulata under cadmium exposure activates Hippo pathway suppression of Yki, revealing a regulatory mechanism in spider cadmium toxicity.
Fish-derived cell lines (PCK and RTG-2) show greater susceptibility to 6PPD-Q toxicity than mammalian cell lines, with pNPA values indicating higher phenotypic perturbations.
Necroptosis is classified into extrinsic and intrinsic subtypes, with distinct mechanisms of trigger sensing and signal integration, involving 3 membrane-bound and 1 intracellular sensor.
Allosteric regulation of LpxC activity introduces a new paradigm for controlling lipopolysaccharide synthesis in Gram-negative bacteria.
- Open access
Covalent caspase inhibitors delivered via GSDMD pores effectively suppress pyroptosis and cytokine release, offering a targeted approach for inflammatory disease treatment.
Gβγ binds multiple sites on PLCβ3 to facilitate activation and reorient the enzyme for maximal PI(4,5)P2 hydrolysis in concert with Gα q.
- Open access
Targeting RAS mutations offers promising strategies for intercepting pancreatic cancer at its precancerous stage.
NINJ2 maintains lysosomal membrane integrity to prevent ferroptosis, with loss increasing susceptibility by 2.5-fold in cell models.
- Open access
CiCIPK8 and CiCIPK11 enhance osmotic stress tolerance in pecan by activating antioxidant defenses and osmolyte accumulation, with significantly improved seed germination and root growth under stress.
- Open access
Human ZBP1 induces cell death more potently than mouse ZBP1, relying on RIPK1 and all three RHIM domains, with distinct signaling mechanisms.
- Open access
Caspase-3 cleaves CYLD at a novel site to limit interferon signaling during mitochondrial apoptosis, reducing inflammation and promoting immune silence.
- Open access
Proteolytic activation of caspase-3 and caspase-7 is essential for distinct physiological processes in mice, with activation controlling different functions in adult tissues.
- Open access
Delta variant-specific ORF3a mutations destabilize lysosomal homeostasis, causing lysosomal damage that triggers inflammatory cell death in SARS-CoV-2.
- Open access
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- bioRxiv6131
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- Sci Adv354
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- Environ Res230
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- Environ Pollution165
- Nat Commun161
- Science141
- Nature138
- Lancet128
- Cell Rep120
- NEJM119
- mBio107
- Plant Cell Environ107
- Curr Biol106
- J Exp Bot106
Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3