Distinct NLR proteins activate inflammasomes through diverse mechanisms, with recent structural advances revealing how they assemble into signaling platforms.
Communications Biology
Nature Portfolio · Cell & Molecular Biology · ISSN 2399-3642
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Diverging coral deoxygenation studies hinder collective understanding, with methodological differences preventing clear comparison of results.
Dysregulation of BUB gene family causes chromosomal instability linked to cancer progression, heterogeneity, metastasis, and therapy resistance.
- Open access
Genetic variation, brain lateralization, and neural circuit organization across development shape number cognition in vertebrates, with zebrafish and chicks as key models.
A human-specific antibody selectively inhibits interleukin-6 trans-signalling while preserving classic signalling, revealing distinct receptor assembly mechanisms.
- Open access
Disruption of KCNQ1 impairs human neuronal development by reducing mitochondrial function, insulin signalling, and synaptic activity in neural cells.
Zebra finches employ an additive integration strategy for auditory sequence recognition, while humans primarily rely on pitch, with experience influencing cue use.
Loss of DNMT1 in cortical PV interneurons increases PV spiking but reduces inhibitory efficacy, leading to network desynchronization and depression- and anxiety-like behaviors in mice.
- Open access
The bacteriophage transcription factor Gp53 suppresses Pseudomonas aeruginosa growth, motility, and biofilm formation by regulating key host genes.
- Open access
Global analyses better recover shared biological signals and are less sensitive to sampling biases than regional diversification rates in marine invertebrates.
- Open access
Coral larval settlement density is significantly predicted by the presence of living bacteria reef ink, structure type, and proximity to acoustic enrichment within 20 meters in Kāne'ohe Bay.
- Open access
Projection target-dependent differences in odor coding are observed in mouse olfactory bulb neurons, with APC-projecting neurons coding more strongly for odor concentration.
ESR1 mutations in breast cancer are linked to increased MTORC1 signaling and higher mutational burden, indicating enhanced tumor proliferation and aggressiveness.
LSD increases alpha and beta peak frequencies and decreases oscillatory power while enhancing neural complexity and fractality in specific cortical networks.
Higher levels of adult hippocampal neurogenesis in mice are linked to broader exploration and greater flexibility in updating action-outcome relations.
Diversity in nutrient sensing by Candida auris is linked to its ability to evade immune responses across different host environments.
- Open access
Salinity influences bacterial community composition more strongly than protists in the Baltic Sea, with bacterial diversity remaining stable despite community shifts across salinity levels.
ALLO-1 regulates mitochondrial stress responses and enables muscle functional recovery before structural repair in C. elegans muscle.
- Open access
Cancer-derived lactic acid may act as an upstream contributor to tumor hypoxia, forming a feedback loop that sustains hypoxic tumor regions.
Dr. Lawrence Fung’s work on neurodiversity and human potential spans neuroimaging and community research, emphasizing autism and neurodiversity at Stanford University.
Milk-grown Staphylococcus aureus exhibits extreme resistance to reactive oxygen species, antimicrobial tolerance, and accelerated killing in a larval infection model compared to serum-grown bacteria.
- Open access
A high-resolution GWAS of nearly 600,000 East Asians identified 196 loci for T2D, including three novel loci, with 74% shared causal signals across populations.
- Open access
Post-prandial Burmese pythons show increased myofibril tension and relaxation rates, with frequent feeding linked to slower myofibril activation, indicating significant cardiac remodeling.
- Open access
The thermodynamic state map of biomolecular condensates predicts measurable material changes and links code disruption to pathogenic liquid-to-solid transitions.
Cryo-EM reveals that human CENP-A nucleosomes in cells assemble as histone octamers with DNA wrapped in a left-handed superhelix, confirming the octameric model.
Recurrent euchromatic deletions on the Y chromosome in male cancer cell lines are linked to transcriptional changes and clinical outcomes, as measured by the new YES Score.
Repurposed in vitro arthritis models can effectively simulate key features of chikungunya virus-induced joint inflammation.
A protocol enables reproducible culture and transcriptome analysis of human Schwann cells from small sural nerve biopsies, facilitating PNP research.
- Open access
Coral-associated denitrification varies seasonally and species-specifically, with rates up to 2.0 nmol N cm -2 h -1 in some corals.
- Open access
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3
