Deletion of SPI1 in microglia worsens amyloid pathology by reducing microglial response and phagocytosis in Alzheimer's disease models.
- Open access
- 5 cites
Neuron
Cell Press · Neuroscience · ISSN 0896-6273, 1097-4199
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- 14.4
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Imagining scenes and speech activates transmodal association networks more than sensory-specific areas, highlighting their role in self-generated mental imagery.
- 3 cites
Cortical and brainstem circuits, especially the ventrolateral periaqueductal gray, causally mediate multimodal placebo analgesia in mice, with lasting effects after injury.
- Open access
- 7 cites
Precision fMRI reveals that individual human LPFC networks are fragmented, interdigitated, and contain conserved motifs not visible in group-averaged data.
- Open access
- 12 cites
Hepatic expression of APOE3 Christchurch reduces amyloid-β burden and AD pathologies in APOE4-expressing APP/PS1 mice.
- 1 cites
Slow-wave sleep engages a PZ GABAergic to LPB CGRP to ovBNST Crh circuit that prevents stress-induced anxiety in mice.
- 1 cites
Latest in Neuron
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Blood biomarkers and digital measures together can improve Alzheimer’s disease care beyond diagnostic accuracy alone.
Hand area of human motor cortex (MC) shows more selective responses to hand movements, while posterior parietal cortex (PPC) strongly represents all effectors, indicating distinct coding patterns.
Chrm2-expressing hippocampal interneurons inhibit hippocampal ripples during NREM sleep and are essential for spatial and social memory consolidation in mice.
Raphe nuclei regulate behavioral state transitions by integrating environmental cues within a distributed neural network across species.
Dynamic transitions between parvalbumin interneuron states are essential for gamma oscillations and are disrupted in J20 Alzheimer's disease mice.
Activation of PBLC glutamatergic neurons induces backward locomotion in mice, highlighting a specific brainstem module for directional control.
Recovery sleep-associated neuronal ensembles in the zona incerta (ZI) mediate analgesia through distinct circuits, with activity reduced by chronic pain in mice.
More sensitive and robust microstructural measures from diffusion MRI reveal adolescent white matter development across 62 brain bundles in over 24,000 datasets.
Whole-genome and transcriptomic profiling of 85 MAPT-mutant iPSC lines reveal unintended editing events and cellular states linked to organoid development.
A novel AAV platform achieves over 90% microglial specificity across multiple species, including mice, rats, rhesus macaques, and human brain slices.
H2A.Z occupancy changes in the hippocampus are sex-specific in AD, decreasing in females and increasing in males, affecting disease outcomes.
Restoring astrocytic μ-crystallin (Crym) in a Huntington's disease mouse model improves early-stage behavioral and cellular abnormalities by 32%, highlighting its potential as a therapeutic target.
Stage-dependent engagement of anterior cingulate cortex circuits underpins sensory hypersensitivity and motivational decline in chronic pain, with distinct projections to BLA and LHb involved.
OFC population dynamics vacillate between competing value states and disrupt striatal population geometry during automatic behavior interruption in monkeys.
Persistent Tau phosphorylation linked to neurodegeneration in Alzheimer's disease may result from dysregulated neuronal adaptive responses rather than a distinct pathological pathway.
Simultaneous awake replay of multiple spatial memories occurs frequently in the hippocampus during reward consumption in rats.
Chronic social defeat stress causes sleep fragmentation by increasing VTA dopaminergic activity, reducing sleep spindle density and disrupting NREM sleep in mice.
Private foundations and governments collaborated with scientists to establish centers that significantly advanced theoretical and computational neuroscience, shaping the field's development.
Interactions between the posterior parietal cortex and pulvinar are necessary to maintain sensory history representations for decision-making in mice.
- Open access
Artificial intelligence is beginning to automate scientific discovery in psychology, with the potential to develop an automated science of the mind.
Understanding the "recipe" for intelligence reveals many parallels between biological and artificial systems, despite many computational problems remaining unsolved in AI.
- Open access
Slow-wave sleep engages a PZ GABAergic to LPB CGRP to ovBNST Crh circuit that prevents stress-induced anxiety in mice.
- 1 cites
Maternal type I interferon signaling causes TREM2 dysregulation and synaptic dysfunction in offspring hippocampus in a neurodevelopmental disorder model.
- Open access
- 2 cites
Large language models encode linguistic diversity into a high-dimensional space that closely parallels neural population codes, suggesting a shared computational strategy.
Modeling human developmental processes in neural architecture enhances the plausibility and capabilities of NeuroAI systems.
Heterozygous SHANK3 +/- macaques exhibit sleep disturbances, social interaction changes, stereotypical behaviors, and altered brain connectivity, modeling autism spectrum disorder features.
- 1 cites
Glial Croquemort (Crq) is essential for synapse elimination during Drosophila development and prevents age-related synaptic loss in adults.
- Open access
- 1 cites
Prolonged exhalation increases risky choices by enhancing reward sensitivity and cardiac parasympathetic activity during decision-making.
- Open access
Potentiation of callosal GABAergic synapses from prefrontal PV neurons onto corticothalamic neurons is linked to cognitive flexibility during rule shifts.
- Open access
- 1 cites
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