DNA Repair Mechanisms
Moving in bioRxiv, Nature Communications, Nature, Cell Reports, eLife, EMBO Journal, EMBO Reports and Frontiers in Genetics.
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- Papers in 60 days
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Latest in DNA Repair Mechanisms
Newest first · last 60 days
Ubiquitin-dependent fate control and isoform diversity safeguard ZUP1, a key ubiquitin chain-editing enzyme, maintaining RPA turnover on ssDNA in cells.
- Open access
Multiple chromosome-specific mechanisms suppress axis protein deposition and DNA double-strand breaks within 20 kb of telomeres in Saccharomyces cerevisiae.
- Open access
Dysregulation of BUB gene family causes chromosomal instability linked to cancer progression, heterogeneity, metastasis, and therapy resistance.
- Open access
TDP2-mediated DNA repair is essential for timely regulation of early response gene transcription in cortical neurons, with Tdp2 deletion causing ERG overexpression and circuit dysfunction.
- Open access
The manuscript on Rad51 and Dmc1 mismatch tolerance in yeast meiosis has been withdrawn due to incorrect assessment of BIR recombination.
- Open access
Oxidative DNA damage at centromeres promotes chromosome instability, with lesions leading to DNA breaks and aneuploidy in pre-tumorigenic cells.
- Open access
BCR signaling strength determines the likelihood of VH gene replacement in peripheral B cells, with weaker signals increasing VHR frequency.
Brca1 coiled-coil domain mutants retain the ability to suppress Group 1 tandem duplications in mouse cells and tumor models despite impaired homologous recombination functions.
- Open access
Loss of rice ZEP1 protein causes asynapsis, multivalent formation, and chromosome fragmentation, disrupting meiotic genome integrity in rice.
- Open access
Interaction between BRCA1 exon 11 and TOPBP1 is essential for DNA end-resection during homologous recombination.
- Open access
DNA double-strand breaks within actively transcribed loci trigger rapid transcription repression through chromatin remodeling and RNAPII modifications to coordinate repair.
SNI1/NSE5 acts as a temperature-sensitive brake on class II crossovers in Arabidopsis, with crossover rates increasing under cold conditions.
- Open access
Inhibition of microhomology-mediated end joining reduces ecDNA levels and impairs cancer cell fitness by targeting TA-rich breakage sites.
- Open access
LaminB2 depletion in zebrafish neural crest cells accelerates nuclear recovery during confinement without increasing DNA damage, indicating a protective role in nuclear deformability.
- Open access
Cohesin's dual functions in chromosome cohesion and chromatin loop extrusion are crucial for genome stability and DNA repair.
Programmable DNA protonuclei reveal that environmental factors like confinement and viscoelasticity critically influence FUS protein phase separation, with a significant impact on disease-related transitions.
- Open access
RO7589831 demonstrates a manageable safety profile and a 74.2% disease control rate in patients with MSI solid tumors in a phase 1 trial.
- Open access
- 1 cites
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
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