Spatial multi-omic atlas reveals distinct hepatocyte- and cholangiocyte-lineage programs and cardiac progenitors in a CS12 human embryo.
- Open access
Nature Cell Biology
Nature Portfolio · Cell & Molecular Biology · ISSN 1465-7392, 1476-4679
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Spatial multi-omic atlas reveals distinct hepatocyte- and cholangiocyte-lineage programs and cardiac progenitors in a CS12 human embryo.
- Open access
Surface Y RNAs on human monocytes are linked to increased inflammation in inflammatory bowel disease and promote immune activation via TLR2 and TLR4.
ADAR1 and FTSJ1 regulate tryptophan-to-phenylalanine mistranslation in cancer cells under tryptophan shortage, with ADAR1 supporting ribosome quality control and FTSJ1 promoting codon reassignments.
Clathrin-mediated endocytosis shows only minor selectivity for cytoplasmic leaflet lipids, with lipid partitioning ranging from slight enrichment to moderate exclusion.
CLN8 is a stereospecific glycerophosphoglycerol acyltransferase essential for BMP biosynthesis, with mutations impairing activity linked to Batten disease.
PI3P-containing ER microdomains, mediated by DFCP1, are essential for lysosomal membrane repair in response to damage.
Meningiomas resemble dura-lineage cells and may originate from dura-like tissue, as shown by transcriptomic similarity in human fetal meninges.
Multiomic analysis of human meningeal development from 6 to 21 weeks reveals gene regulatory networks, immune origins, and cell interactions linked to barrier immunity.
DePass achieves superior integration accuracy across 6 modalities, 9 tissue types, and 13 platforms in single-cell and spatial multi-omics data.
- Open access
- 1 cites
LaminB2 depletion in zebrafish neural crest cells accelerates nuclear recovery during confinement without increasing DNA damage, indicating a protective role in nuclear deformability.
- Open access
CLN8 enables an alternative glycerophospholipid synthesis pathway that produces BMP, which is essential for lysosomal lipid homeostasis, and its deficiency causes lipid accumulation.
Bipartite active X chromosome structure dissolves in liver cancer tissues, with disruption linked to premalignant transition in mice and humans.
EZH2 and SREBP2 form a regulatory axis that promotes cholesterol biosynthesis and supports tumor growth, with EZH2-targeting PROTACs degrading both proteins to inhibit tumors.
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
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- Bacteriophages and microbial interactions4
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