Hybridization occurs across nearly all eukaryotic lineages, with estimates suggesting it is more common and influential in evolution than previously thought.
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Nature Reviews Genetics
Nature Portfolio · Genomics & Bioinformatics · ISSN 1471-0056, 1471-0064
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Deep learning-based tools for small variant calling in long-read sequencing have transformed detection across diverse biological contexts, including germline, de novo, somatic, and mosaic variants.
Single-cell and spatial genomics reveal complex gene regulation in trophoblasts at the human maternal-fetal interface.
Multi-omics and computational frameworks have significantly advanced understanding of epithelial-mesenchymal transition (EMT) by enabling comprehensive profiling of cellular states at unprecedented resolution.
Mitochondrial DNA errors tend to accumulate over generations but are counteracted by mechanisms that preserve mtDNA integrity in most species, including humans.
Multimodal lineage tracing combined with deep learning enhances the accuracy of cell fate and trajectory analysis in single-cell multi-omic data.
Cohesin's dual functions in chromosome cohesion and chromatin loop extrusion are crucial for genome stability and DNA repair.
Genetic variation in core circadian genes and circadian misalignment are linked to human disease risk, progression, and therapeutic response.
Sequence-based deep learning predicts genetic variant effects at base-pair resolution to enhance crop breeding strategies.
Machine learning and statistical methods enhance molQTL mapping to better connect genetic variation with molecular phenotypes.
Specialized reader proteins and transcription factors interpret DNA methylation to regulate gene expression and chromatin structure in mammals and plants.
Plasmids and extrachromosomal DNA share key evolutionary capacities, acting as contingency loci that enable rapid adaptation across bacteria and cancer cells.
Recent advances in genomic methods and ancient DNA analysis have enhanced detection of natural selection signatures in human genomes over the past 10,000 years.
Genomic data and genetic tools have established danionin fishes, including zebrafish, as key models for studying phenotypic divergence and evolutionary innovations.
Programmed DNA elimination occurs across diverse eukaryotes with significant mechanistic diversity and evolutionary recurrence, affecting genome integrity and cellular processes.
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