Gene regulation map of the human fetal heart reveals that both rare coding and common noncoding variants associated with CHD converge on valvular interstitial cells (VICs).
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Congenital heart defects research
Moving in bioRxiv, Stem cell research, medRxiv, Communications Biology, eLife, EMBO Journal, EMBO Reports and Frontiers in Genetics.
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Latest in Congenital heart defects research
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A human iPSC line from a male HCM patient with a heterozygous TPM1 c.644C>T mutation exhibits normal karyotype and differentiation potential.
- Open access
A human induced pluripotent stem cell line from an arrhythmogenic cardiomyopathy patient with DSG2 c.2358delA variant was successfully generated and characterized.
- Open access
CDC42 regulates reactive oxygen species to control Paneth cell identity and antimicrobial function in the small intestine.
- Open access
Sulf1 modulates TGF-β-dependent epicardial activation and inflammation, with its disruption causing regeneration defects and increased fibrosis in zebrafish hearts.
- Open access
YAP1 induces hepatocellular carcinoma through DNA demethylation, not canonical driver gene mutations, with widespread demethylation activating oncogenes in mouse models.
- Open access
Single-nucleus transcriptomic atlas reveals key cell types and developmental mechanisms in human inner ear, highlighting vulnerabilities linked to disease genes.
- Open access
Primordial cardiomyocytes are essential for heart development but not necessary for regeneration in zebrafish, with only 15% capable of regeneration after injury.
- Open access
Children with CHD7-mutant congenital heart disease and neurodevelopmental abnormalities exhibit distinct serum metabolomic profiles, especially in steroid hormone and amino acid metabolism, with 11-deoxycortisol and 2-hydroxyestrone as potential markers.
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Topics moving, week to 23 Oct 2026
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