Early lineage divergence in the embryonic mouse thalamus segregates sensory and motor-associative identities from distinct progenitor domains.
- Open access
Nature Neuroscience
Nature Portfolio · Neuroscience · ISSN 1097-6256, 1546-1726
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Elevated ABCA1 expression in the substantia nigra is linked to cholesterol overload and neurodegeneration in Parkinson's disease mouse models and postmortem brains.
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Elevated ABCA1 expression in the substantia nigra is linked to cholesterol overload and neurodegeneration in Parkinson's disease mouse models and postmortem brains.
Early lineage divergence in the embryonic mouse thalamus segregates sensory and motor-associative identities from distinct progenitor domains.
- Open access
Spatiotemporal remodeling of LHb gene expression and neuronal activity marks the onset of depression-related phenotypes in male mice after chronic stress.
Amygdala interbrain representational alignment during mutual cooperation predicts trial outcomes in social dilemmas.
A half-center oscillator in Drosophila sleep-control neurons produces slow-wave activity that is causally linked to sleep regulation.
Seal uncovers a significant burden of de novo regulatory variants in transient fetal excitatory neurons in autism, revealing cell-type- and stage-specific effects.
5-HT(2A) receptors in layer 5 pyramidal neurons mediate psilocybin-induced neuroplasticity but are not required for hallucinations in rodents.
Elevating Pla2g2f in hippocampal dentate granule cells during aging prevents cognitive decline and associated neurophysiological changes in mice.
Periventricular gradient pathology in MS is linked to ependymal reactivity and disruption of cell adhesion, involving immune activation and transporter dysregulation.
Disordered neural circuits with circular symmetry can function as continuous attractors, as shown by data-driven recurrent networks modeling rodent head-direction cells.
- 1 cites
A common CCG repeat expansion in FAM193B is significantly associated with increased Alzheimer's disease risk, with an odds ratio of 2.20 per 10-repeat increase.
LSD occupies 5-HT2AR with high affinity and increases global cerebral blood flow and internal carotid artery flow in humans.
Mendelian randomization and multiomics analyses identified 19 druggable targets for Alzheimer's disease, including protective variants in EPHX2, in individuals of European and African ancestry.
- Open access
The human superior colliculus shows modality-specific predictive responses to visual and somatosensory stimuli, with distinct depth-dependent activity patterns observed in 80 layers.
Astrocytes with C9ORF72 mutation disrupt mitochondrial transport in motor neuron axons, but boosting astrocytic bioenergetics rescues this deficit.
Human claustrum neurons encode uncertainty and prediction errors during aversive learning, with distinct temporal profiles compared to anterior cingulate cortex.
Structured early experience promotes flexible, generalizable strategies and neural activity reflecting task temporal structure in mice and RNNs.
Mitochondrial plaques develop in AD model mice due to impaired mitophagy and lysosomal dysfunction, with large accumulations of mitochondria forming in neuronal processes.
Striatal endocannabinoid-mediated long-term potentiation (eCB-LTP) enables one-shot learning in mice, with a single contact inducing plasticity and memory formation.
A neuroprosthesis decoding attempted finger movements achieves 110 characters per minute with 1.6% error in two individuals with paralysis.
- Open access
- 2 cites
Twenty-one morphological, twelve electrical, and nine input neuronal types are identified among 1,130 mouse insular pyramidal neurons, revealing cellular diversity and specialization.
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