STRIDE-III updates IBD treatment targets, defining 13,071 records and establishing three categories of targets to guide treat-to-target care.
The lancet. Gastroenterology & hepatology
Elsevier BV · Clinical Medicine · ISSN 2468-1253
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Simedeutirom at 80 mg and 160 mg significantly increased MASH improvement rates without fibrosis worsening compared to placebo in Chinese patients with metabolic dysfunction-associated steatohepatitis.
Personalized neoantigen vaccines, especially mRNA-based approaches, can elicit high-magnitude CD8+ T-cell responses and long-lived clonal persistence in postoperative PDAC.
Restoring gut barrier function with targeted therapies may transform treatment of disorders of gut-brain interaction.
A blood-based assay detects colorectal cancer and advanced adenomas with 95% accuracy in a multicentre study, showing 91% sensitivity for colorectal cancer and 81% for advanced adenomas.
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AI-assisted colonoscopy did not significantly increase adenoma detection rate in Lynch syndrome surveillance, with a difference of 2.9% (p=0.41) in a multicentre trial.
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DD01 achieved a 76% rate of at least 30% liver fat reduction at 12 weeks in adults with MASLD or MASH, significantly surpassing the 12% in the placebo group.
Bowel endometriosis affects 8-12% of women with endometriosis, most commonly involving the rectosigmoid colon and often coexisting with other pelvic lesions.
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