Autophagy in Disease and Therapy
Moving in Virulence.
- Moved, week to 23 Oct 2026
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- Papers in 60 days
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Latest in Autophagy in Disease and Therapy
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Bruce inhibits wing tissue growth in Drosophila by regulating autophagy-dependent activation of non-lethal caspase Dcp-1.
- Open access
V. dahliae infection in Arabidopsis triggers significant lipid metabolism changes, including accumulation of lysophospholipids and activation of phospholipase A genes.
USP9X is essential for degrading ubiquitinated eRF1 on collided ribosomes by trimming K6-linked ubiquitin chains in quality control pathways.
- Open access
Loss of Aim11 in mitochondria causes accumulation of assembly intermediates of cytochrome c oxidase and ATP synthase in yeast.
- Open access
ALLO-1 regulates mitochondrial stress responses and enables muscle functional recovery before structural repair in C. elegans muscle.
- Open access
CMA regulates a broad range of physiological functions and its dysfunction in ageing and disease causes cellular changes beyond damaged protein accumulation.
Lysosomal lipid and protein changes in the aging brain show increased myelin components and disrupted sphingolipid breakdown, especially in microglia, indicating dysfunction.
- Open access
AMBRA1 allosterically activates NLRP3 by destabilizing its autoinhibited conformation, promoting transition to an active state in inflammatory responses.
Disruption of ROS rhythm through dual inhibition of IDO1 and AhR significantly prolongs survival in NSG mice with tumors.
- 1 cites
Lysosomal stress activates a TBK1/ULK1 pathway that inhibits FLCN and promotes TFEB-driven tumor growth, with mutations in v-ATPase amplifying this effect.
Oncogenic viruses induce LAMP2A SUMOylation via TRIM32, activating CMA to promote tumor growth and viral persistence in vivo.
LAPTM4A enhances mTORC1 signaling, promoting pathological cardiac hypertrophy in mice and humans, with deletion reducing hypertrophy and fibrosis.
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- Science141
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- Lancet128
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3