Electrostatic attraction alone can compact and sequester fragmented chromatin during apoptosis, preventing DNA release into extracellular vesicles.
- Open access
Nuclear Structure and Function
Moving in bioRxiv, Nature Cell Biology, Nature Communications, Communications Biology, EMBO Reports, Nature Reviews Molecular Cell Biology, Stem cell research and Cell Reports.
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Latest in Nuclear Structure and Function
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The NuRD complex modulates RNA polymerase III activity at highly expressed tRNA gene clusters, influencing the cellular tRNA pool's dynamic range.
- Open access
Nuclear-BRITE enables fast, single-molecule live-cell imaging of nuclear RNAs with reduced background noise, surpassing previous MS2 system limitations.
A/B chromatin compartments in mouse embryonic stem cells show a sudden increase in strength during S-phase, indicating unexpected plasticity across interphase.
- Open access
RNA polymerases II and III form dynamic, spatially distinct nuclear foci at the C. elegans 5S rDNA-SL1 gene cluster, with Pol II foci being temperature-sensitive.
- Open access
Inducible hiPSC lines with controlled Progerin expression enable modeling of cellular aging, with successful integration confirmed by PCR and sequencing.
- Open access
Near-atomistic simulations with OpenCGChromatin reveal that H4K16 and H3K9 modifications most disrupt chromatin compaction by weakening tail interactions.
- Open access
Vimentin loss impairs DNA repair and enhances glioblastoma cell survival under genotoxic stress, especially when nuclear compression is induced.
- Open access
Mitotic slippage-induced whole-genome duplication causes widespread nuclear instability in polyploid cells.
- Open access
Necroptosis is classified into extrinsic and intrinsic subtypes, with distinct mechanisms of trigger sensing and signal integration, involving 3 membrane-bound and 1 intracellular sensor.
LaminB2 depletion in zebrafish neural crest cells accelerates nuclear recovery during confinement without increasing DNA damage, indicating a protective role in nuclear deformability.
- Open access
FBXL21 regulates diurnal proteostasis in skeletal muscle by mediating degradation of DNAJB6 and its client proteins, including Desmin and TDP-43.
- Open access
Programmable DNA protonuclei reveal that environmental factors like confinement and viscoelasticity critically influence FUS protein phase separation, with a significant impact on disease-related transitions.
- Open access
Yeast adaptors Ent5 and Sla2 undergo LLPS, with Ent5's disordered helix and Sla2's coiled-coil region mediating condensate formation.
- Open access
A 12-amino-acid stretch within the STAT5 transactivation domain is essential for its nuclear import, with residues D754 and D758 being critical for this process.
- Open access
A novel ∼54-kDa protein, MSEP, encoded by the ARHGEF17-AS1 locus, is essential for mitotic spindle organization and localizes to spindle poles.
- Open access
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Topics moving, week to 23 Oct 2026
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