Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Moving in bioRxiv, Blood, Cellular & molecular immunology, Gastroenterology, Nature Immunology, Cancer Discovery, eLife and EMBO Journal.
- Moved, week to 23 Oct 2026
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Latest in Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Newest first · last 60 days
Membrane-bound DNaseX is recruited early to macrophage phagocytic cups, exhibiting rapid DNase activity before phagosome internalization.
- Open access
TGF-β-PDL1 signaling in neutrophils maintains lung barrier integrity during hyperinflammation by regulating neutrophil behavior in murine models.
- Open access
Elevated reactive oxygen species (ROS) stimulate Paneth cell plasticity and reduce their antimicrobial peptide production, impairing intestinal innate defense.
- Open access
A senescent-like neutrophil subset marked by BHLHE40 is enriched in colorectal cancer liver metastasis and linked to poor prognosis.
Neutrophils in pancreatic cancer liver metastases take up tumor fragments via trogocytosis and modulate macrophages through C3-dependent signaling, limiting immunosuppressive macrophage development.
- Open access
Neutrophil-integrated syncytial CAR macrophages significantly enhance tumor infiltration and reduce tumor burden in mouse models of cancer.
Membrane vesicles (MVs) are generated within Staphylococcus aureus biofilms and serve as carriers of key matrix components, contributing to biofilm formation.
- Open access
Neutrophils predominantly promote tumor growth and metastasis in cancer, but can also mediate tumor cell killing depending on environmental cues.
Retinoic acid promotes expansion of CD177+ neutrophils that drive steroid-resistant GI-GVHD, with RA receptor inhibition restoring steroid sensitivity in models.
- Open access
Mitiperstat, an MPO inhibitor, did not improve symptoms or exercise capacity in 711 patients with heart failure and preserved or mildly reduced ejection fraction over 48 weeks.
The G2019S mutation in LRRK2 enhances NADPH oxidase-2 activity in neutrophils, improving bacterial infection control in mice by 2- to 3-fold.
NADPH oxidases (NOXs) are key regulators of immune, metabolic, and environmental signals, with recent studies revealing their structures, regulatory mechanisms, and roles in disease, especially in immune and tumor contexts.
- Open access
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
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- Alzheimer's disease research and treatments3
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