Tryptophan and brain disorders

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Preconceptional social isolation alters inflammatory and transcriptional signalling across the placenta-fetal brain axis
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.10.01.755920
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Basal Ganglia Dopamine Availability and Immune Activation Interact and Relate to Anhedonia Severity among Youth with Depression
bioRxiv · 7 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.23.696320
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Reactive oxygen species alter ex vivo dopaminergic and purinergic signaling and microglia physiology in the nucleus accumbens
bioRxiv · 7 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.01.722235
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Behavioral, Cardiovascular, and Neuroinflammatory Effects of 3-Aminobenzamide in a Rodent Model of Chronic Psychological Stress
bioRxiv · 6 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.28.721400
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Distinct Hippocampal Cellular Pathologies Influence Cognition Across Diagnostic Categories and Distinguish Schizophrenia from Affective Psychoses
bioRxiv · 5 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.27.720978
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Qualia NAD+(R) Increases NAD+ Levels In Human Participants: A Double-Blind, Placebo-Controlled Study
medRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.03.19.25324259
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IDO1 regulating ROS rhythm reveals glycogenolysis/PPP as a cancer treatment target.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
Disruption of ROS rhythm through dual inhibition of IDO1 and AhR significantly prolongs survival in NSG mice with tumors.
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https://jclub.com.au/a/41826762
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Modeling maternal immune activation in 3D ex vivo human fetal brain cerebroids reveals IL-17A-driven disruption of cortical development.
Nature Neuroscience · 1 Oct 2026 · Journal Article
IL-17A causes premature cortical folding, increased cortical thickness, and accelerated neurogenesis in human fetal brain cerebroids.
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https://jclub.com.au/a/42581194
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Disorder-specific and shared genetic architecture underlying schizophrenia and bipolar disorder
medRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.07.26357436
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A Mechanistic Model for the HPA Axis Cortisol Paradox in PTSD
bioRxiv · 28 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.13.681561
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Postnatal maternal separation alters caregiving patterns but fails to promote anxiety- and depressive-like behaviour in C57BL/6N mouse dams
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.753354
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Xenon improves autism-like behaviors in mice through potentiation of PVT-CeA glutamatergic neurotransmission
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.753714
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Integrated multi-omics analysis identifies microbial and metabolic signatures and drivers of CNS autoimmunity.
mSystems · 22 Sept 2026 · Journal Article
Microbial and metabolic signatures, especially microbial metabolites like p-cresols and indoles, drive CNS autoimmunity severity in a mouse model of MS, with diet-microbiome interactions shaping disease outcomes.
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Do Symptom Domains Have Similar Cellular Underpinnings Across Psychiatric Diagnoses: Evidence from 3D Hippocampal MR Spectroscopy
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.27.721016
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A de novo human MYCBP2 variant enhances memory persistence across species
medRxiv · 18 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.12.18.24319147
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GABAergic interneuron pathology in schizophrenia: a systematic review and meta-analysis across cell-types, brain areas, and cortical layers
bioRxiv · 18 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.23.655812
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Investigation of sex- and age-specific effects of genetics risk for depression on peripheral biomarkers
medRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2022.11.20.22282570
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Subchronic PM(2.5) exposure exacerbates chronic stress-induced depression-like pathology in mice.
Environmental research · 15 Sept 2026 · Journal Article
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https://jclub.com.au/a/42508559
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Kynurenic acid mitigates poststroke brain damage through the gut-brain neural circuit.
Gut · 7 Sept 2026 · Journal Article
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https://jclub.com.au/a/41633810
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Immunotherapy with a short-lived anti-PD-L1 antibody in Alzheimer's disease: a phase 1b, randomized, double-blind trial.
Nature Medicine · 1 Sept 2026 · Randomized Controlled Trial
A short-lived anti-PD-L1 antibody was safe and well tolerated in early Alzheimer's disease patients at doses up to 30 mg/kg, supporting further clinical development.
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https://jclub.com.au/a/42458012
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Gut microbiota-derived lysine phenylacetylation impairs mitochondrial function and is alleviated by SIRT3.
Cell Metabolism · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42341761
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Single-cell atlas of transcriptomic vulnerability across brain disorders.
Nature · 1 Sept 2026 · Journal Article
Single-cell transcriptomic analysis of 6.3 million nuclei from 1,494 donors reveals shared and distinct molecular signatures across eight brain disorders, including Alzheimer’s disease.
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https://jclub.com.au/a/42778699
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GABA takes the edge off anti-tumour immunity.
Nature Reviews Cancer · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42458014
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Beyond Viral Load: A Mechanistic Model of Virus-Immune Dynamics and Age-Dependent Influenza Severity
bioRxiv · 31 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.26.714633
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Progress and challenges in exploring the pathogenesis of depressive disorders via RNA sequencing.
Frontiers in Genetics · 28 Aug 2026 · Review
RNA sequencing reveals shared immune-inflammatory, synaptic, and mitochondrial dysfunctions across diverse depressive disorders, advancing understanding of their molecular basis.
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https://jclub.com.au/a/42729848
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Maternal-fetal immune conflict contributes to male-specific impairments in a mouse model of neurodevelopmental disorders
bioRxiv · 27 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.02.703351
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Systematic analysis of network-driven adaptive resistance to CDK4/6 and oestrogen receptor inhibition using meta-dynamic network modelling.
eLife · 27 Aug 2026 · Journal Article
Heterogeneity in protein signalling networks, especially reaction coefficients, drives adaptive resistance to CDK4/6 and oestrogen receptor inhibitors, as shown by MDN modelling.
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https://jclub.com.au/a/42658196
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