Endoplasmic Reticulum Stress and Disease
Moving in bioRxiv, EMBO Journal, EMBO Reports, Frontiers in Genetics, Cellular & molecular immunology, Communications Biology, Journal of Experimental Botany and Molecular therapy. Nucleic acids.
- Moved, week to 23 Oct 2026
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- Papers in 60 days
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Latest in Endoplasmic Reticulum Stress and Disease
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p97-mediated proteostasis is essential for late-stage thymocyte positive selection, with its loss causing a severe block in CD8+ lineage development in mice.
Oncogenic viruses induce LAMP2A SUMOylation via TRIM32, activating CMA to promote tumor growth and viral persistence in vivo.
HSP70 depletion in HeLa cells causes over 90% reduction in transcript and protein levels, leading to a 1.8-fold increase in misfolded/aggregated proteins.
- Open access
Replication stress in cancer is linked to genomic instability and tumor progression, with ATR-CHK1 pathway playing a key role in preventing catastrophic genome fragmentation.
Unconventional protein secretion offers new design principles to enhance rapid control of extracellular protein release in mammalian cells.
- Open access
FAF1 and FAF2 significantly boost p97-UFD1-NPL4 complex activity, increasing substrate unfolding efficiency by engaging key cofactors and conserved activation motifs.
- Open access
Autophagy plays a complex, dual role in cancer, supporting tumor survival and immune responses, making it a challenging but promising therapeutic target.
- 1 cites
CaSAP8 and CaDSK2a form a negative feedback loop that dynamically regulates thermotolerance in pepper, with CaSAP8 enhancing and CaDSK2a attenuating heat stress responses.
- Open access
- 1 cites
Atg23 prevents inappropriate fusion of Atg9 vesicles during autophagosome formation in yeast, ensuring proper membrane delivery for autophagy.
- Open access
The ER-Golgi intermediate compartment acts as a central stress-responsive hub, integrating membrane trafficking and immune responses, with over 50 key functions identified.
- Open access
Endosome-associated lc3b mRNA is locally translated in axons, facilitating endosomal clearance through autophagy, with over 50% of endosomes showing LC3B colocalization.
- Open access
Disruption of TTN uORFs does not increase titin expression in human cardiomyocytes, revealing context-dependent regulation of TTN translation.
- Open access
Novel compound heterozygous SIL1 variants linked to Marinesco-Sjögren syndrome in a Chinese girl impair SIL1-BiP interaction and reduce protein levels.
- Open access
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Topics moving, week to 23 Oct 2026
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