MAIT cells exhibit tissue-dependent responses to S. aureus and show variable sensitivity to HlgAB toxin, with tonsillar MAIT cells being notably resistant.
- Open access
Immune Cell Function and Interaction
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Allosteric disulfide bond switching in KIR2DL4 regulates HLA-G binding and endocytosis, with the Cys10-Cys28 bond controlling receptor activation in human NK cells.
- Open access
Human CD1c-autoreactive T-cells exhibit cytotoxic responses and reduce Mtb burden in infected antigen-presenting cells, with 50% showing enhanced activation during infection.
- Open access
Cysteine reactivity profiling uncovers metabolic rewiring that impairs T cell function, with significant changes linked to stress pathways and ATP depletion in dysfunctional human T cells.
- Open access
- 1 cites
Allosteric regulation of LpxC activity introduces a new paradigm for controlling lipopolysaccharide synthesis in Gram-negative bacteria.
- Open access
Monocyte-derived galectin-1(hi) cells are essential for the formation and maintenance of lung CD8+ tissue-resident memory T cells after influenza infection.
- 1 cites
HnRNPK deficiency in germinal center B cells markedly increases plasma cell differentiation and reduces germinal center B-cell numbers by up to 50%.
Intratumoral T cell activation can eliminate tumors without tumor-specific T cell receptor involvement, relying solely on paracrine signaling and innate immune responses.
Transient depletion of T reg cells during the hair's anagen phase triggers autoimmune hair loss in mice, with 100% developing alopecia under these conditions.
γδ T cell receptor (TCRγδ) dependencies define a distinct immunosurveillance modality crucial for rapid tissue stress and carcinogenesis responses.
- Open access
Targeting ZMYND8 in CD8+ T cells enhances IL-2 signalling and promotes effector-like states, improving antiviral and antitumour responses in models of exhaustion.
- Open access
A novel Fab-dimerized glycan (FDG) antibody with a dual-glycan clamp epitope was isolated, showing approximately 30% breadth against HIV-1 and unique architecture.
- Open access
DGKα and ζ deficiency in Tregs causes destabilization and conversion to pathogenic exTreg-Tfh2 cells, triggering IgG1/IgE autoantibody-driven multiorgan autoimmunity.
- Open access
- 1 cites
Proliferation and cell death fluctuations in mature NK cell subsets generate clonal heterogeneity during MCMV infection in mice.
- Open access
BHLHE40 orchestrates intestinal immunity by regulating ILC3s and RORγt⁺ APCs, crucial for mucosal defense and tolerance, with a 40-fold increase in expression during inflammation.
- Open access
Allogeneic BCMA CAR T cells armed with NKG2A receptor (CT0590) effectively resist host NK cell attacks and show durable responses in multiple myeloma patients.
Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells drives preclinical autoimmunity in mice, linking gut microbes to systemic autoimmune features.
- Open access
Lactate-α-ketoglutarate metabolic circuit in tumor-infiltrating Treg cells promotes tumor progression by inducing NK cell senescence, with GDH1 as a key driver.
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
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- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3