Cancer, Hypoxia, and Metabolism
Moving in bioRxiv, Cell Reports, Frontiers in Genetics, Cancer Research, Nature Cancer, Nature Communications, Cancer Discovery and Nature Chemical Biology.
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- Papers in 60 days
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Latest in Cancer, Hypoxia, and Metabolism
Newest first · last 60 days
Increased MTFP1 expression promotes pancreatic ductal adenocarcinoma liver colonization by enhancing mitochondrial metabolism reprogramming through the ROS/PI3K/AKT/c-MYC/SLC1A5 pathway.
- Open access
- 7 cites
MYC-driven tumor metabolism varies with tissue type, microenvironment, and systemic factors, revealing context-dependent vulnerabilities that may inform targeted therapies.
Acidic tumor microenvironment induces PARPi resistance in epithelial ovarian cancer through p300-dependent mechanisms.
Nuclear OXCT1 reduces MHC-I gene transcription by suppressing histone β-hydroxybutyrylation in hepatocellular carcinoma cells.
Loss of KDM6A universally activates oxidative phosphorylation across multiple cancer types and tissues, revealing tissue-specific mechanisms and convergent evolution.
- Open access
Loss of MTAP in pancreatic ductal adenocarcinoma (PDAC) increases BCAT1 expression by DNA demethylation, leading to a 2.5-fold BCAA dependency that promotes tumor progression.
- Open access
Cancer cells in breast tumors exploit LACTB's autoproteolytic activity, leading to its self-degradation and inactivation, with LACTB's activity modulated by increased MRPS34 levels.
- Open access
Canonical Notch2 signaling is essential for the development, maintenance, and function of iron-recycling macrophages, with its disruption causing iron overload in mice.
- Open access
ACLY palmitoylation driven by palmitic acid enhances macrophage histone acetylation, suppressing hepatocellular carcinoma progression by reprogramming the tumor microenvironment.
- Open access
Acetate inhibits esophageal squamous cell carcinoma growth by activating an ACSS2-dependent H2A.Z acetylation pathway, with low acetate and ACSS2 linked to poor prognosis.
- Open access
Correction to the article on cancer cell metabolism and tumor microenvironment remodeling clarifies previous findings and updates key data.
- Open access
An iron-dependent methionine redox pathway is essential for adipose browning and influences cachexia progression in mouse models.
- Open access
- 1 cites
Mitochondrial dysfunction and genetic-epigenetic cascades drive drug-tolerant states across lung cancer subtypes.
- Open access
Inhibiting autophagy with ATG7 silencing nanoparticles enhances radiotherapy effectiveness in high-grade mutant IDH1 gliomas, leading to tumor regression and long-term survival.
- Open access
IDH3A-driven citrate accumulation controls metabolic fitness and venetoclax resistance in AML stem cells, with knockdown impairing leukemia maintenance.
NDST2-driven N-glycosylation of EGFR at four conserved sites promotes lenvatinib resistance in hepatocellular carcinoma, with NDST2 upregulation correlating with resistance.
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3