Cellular transport and secretion
Moving in bioRxiv, eLife, Nature Communications, EMBO Reports, Cell Reports, Nature Plants, EMBO Journal and Nature Chemical Biology.
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Latest in Cellular transport and secretion
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Syntaxin11 deficiency inhibits CRAC channel priming, reducing calcium entry and gene expression in T lymphocytes independently of membrane trafficking, with implications for immune disorders.
- Open access
Mammalian ER membranes are primarily composed of phosphatidylcholine and monounsaturated glycerophospholipids, indicating a highly compressible bilayer.
- Open access
DcrB acts as a molecular safeguard in Escherichia coli by promoting Lpp maturation and preventing toxic inner membrane-peptidoglycan linkages, especially under stress conditions.
- Open access
Rab5 and Rab11 regulate distinct developmental events in neural circuit assembly through endocytic trafficking pathways.
- Open access
Low-frequency depression (LFD) at mammalian synapses results from synaptic vesicle undocking, not depletion of the readily releasable pool, and is immediately reversible by high-frequency stimulation.
- Open access
Membrane-bound DNaseX is recruited early to macrophage phagocytic cups, exhibiting rapid DNase activity before phagosome internalization.
- Open access
SNX17 is essential for efficient Rift Valley fever virus infection, with its removal causing a substantial reduction in infection rates in knockout cells.
- Open access
BbCrpa2, a plasma membrane P4-ATPase in Beauveria bassiana, is a key determinant of CsA resistance by mediating its endocytic internalization with 100% dependence on AP2-clathrin pathways.
- Open access
Most large extracellular vesicles (lEVs) exceeding 200 nm originate from the plasma membrane and include diverse subtypes with distinct biogenesis pathways.
Most gp41-directed broadly neutralizing antibodies allosterically stabilize the prefusion-closed Env state, while the bivalent 10E8.4/iMab antibody favors both closed and open states.
- Open access
Genetic variation influences in vivo protein-protein interaction strength, with 12,000 SNPs linked to 61 PPIs in Saccharomyces cerevisiae, revealing significant piQTLs.
- Open access
- 1 cites
Phosphoglycerate kinase 1 (PGK1) forms a novel coat protein complex with AP2, promoting endocytosis by acting as a cargo adaptor and stabilizer of the AP2 complex.
- Open access
SMF-1 pilus forms antiparallel bundles that facilitate rapid biofilm initiation in Stenotrophomonas maltophilia, revealing a unique structural mechanism for bacterial colonization.
- Open access
Targeting oncomucin-driven immune suppression enhances K-ras(G12D) inhibitor efficacy in pancreatic cancer by reducing tumor burden and immune checkpoints.
- Open access
- 1 cites
Lysosomal stress activates a TBK1/ULK1 pathway that inhibits FLCN and promotes TFEB-driven tumor growth, with mutations in v-ATPase amplifying this effect.
Gβγ binds multiple sites on PLCβ3 to facilitate activation and reorient the enzyme for maximal PI(4,5)P2 hydrolysis in concert with Gα q.
- Open access
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Topics moving, week to 23 Oct 2026
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- Alzheimer's disease research and treatments3
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