Mitochondrial dysfunction across diverse brain cell types accelerates aging, with evidence showing impairments in neurons, glia, and vascular cells contributing to cognitive decline.
- Open access
- 3 cites
Mitochondrial Function and Pathology
- Moved, week to 23 Oct 2026
- 2
- Papers in 60 days
- 71
Add Mitochondrial Function and Pathology as an interest in JClubFree on iPhone and Android · interests shape Home, Discover and your digest
Rebuilt
Moved this week
Cardiolipin deficiency in mitochondria impairs electron transport chain function and causes steatohepatitis in mice and humans.
- Open access
- 3 cites
Latest in Mitochondrial Function and Pathology
Newest first · last 60 days
Bayesian inference reveals that key parameters of C3 photosynthesis can be reliably estimated from a single A-Ci curve, but others require expanded light response sampling.
- Open access
Cysteine oxidation of DLAT inhibits PDH activity and promotes a Warburg-like metabolic shift under oxidative stress in mouse and human tissues.
- Open access
Increased MTFP1 expression promotes pancreatic ductal adenocarcinoma liver colonization by enhancing mitochondrial metabolism reprogramming through the ROS/PI3K/AKT/c-MYC/SLC1A5 pathway.
- Open access
- 7 cites
Loss of Aim11 in mitochondria causes accumulation of assembly intermediates of cytochrome c oxidase and ATP synthase in yeast.
- Open access
ALLO-1 regulates mitochondrial stress responses and enables muscle functional recovery before structural repair in C. elegans muscle.
- Open access
Mitochondrial DNA errors tend to accumulate over generations but are counteracted by mechanisms that preserve mtDNA integrity in most species, including humans.
Mitochondrial DNA acts as a primary evolutionary engine driving nuclear coadaptation, expanding mitonuclear haplotype pools within species.
CRISPR/Cpf1 editing of DNM1L in human iPSCs produces a mutant line with normal morphology, stability, and differentiation capacity.
- Open access
Loss of rice ZEP1 protein causes asynapsis, multivalent formation, and chromosome fragmentation, disrupting meiotic genome integrity in rice.
- Open access
Excised leaf samples in Arabidopsis show more photosystem II damage and less thylakoid structural change after high-light treatment than intact plants, highlighting the importance of sample integrity.
- Open access
Cancer cells in breast tumors exploit LACTB's autoproteolytic activity, leading to its self-degradation and inactivation, with LACTB's activity modulated by increased MRPS34 levels.
- Open access
The human Mic60-Mic19 subcomplex forms a dynamic tetrameric structure that acts as a diffusion barrier at mitochondrial crista junctions, with a key role in mitochondrial regulation.
- Open access
Add Mitochondrial Function and Pathology as an interest in JClub
Browse JClub
Journals this month
- bioRxiv6131
- medRxiv1703
- PNAS447
- Sci Adv354
- JAMA262
- Environ Res230
- BMJ182
- Environ Pollution165
- Nat Commun161
- Science141
- Nature138
- Lancet128
- Cell Rep120
- NEJM119
- mBio107
- Plant Cell Environ107
- Curr Biol106
- J Exp Bot106
Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3