Cancer-related gene regulation

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Quinone reductase 2 reads H3 serotonylation to support human cortical neuron development
bioRxiv · 21 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.17.712426
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TGS1 mediates mRNA 5'-cap trimethylation to promote oxidative phosphorylation in acute myeloid leukaemia.
bioRxiv · 19 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.18.712389
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Author Correction: Histone H3 proline 16 hydroxylation regulates mammalian gene expression.
Nature Genetics · 14 Oct 2026 · Published Erratum
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https://jclub.com.au/a/42875587
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PRMT5 inhibition induces a histone methylation switch that drives chromatin plasticity, drug resistance, and metastatic progression
bioRxiv · 10 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.30.702866
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DNA Methylation Signatures in Breast Cancer: A Systematic Review and Meta-Analysis
bioRxiv · 8 Oct 2026 · Preprint
A meta-analysis of 144 breast cancer samples reveals a common DNA methylation pattern across all subtypes, notably involving immune system and cell cycle deregulation.
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https://jclub.com.au/a/10.1101/2022.10.15.512358
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Blocking the m(6)Am methyltransferase PCIF1 in macrophages attenuates colitis progression by preventing neuronal damage.
Cellular & molecular immunology · 1 Oct 2026 · Journal Article
Blocking the m(6)Am methyltransferase PCIF1 in macrophages reduces colitis progression and protects enteric neurons from inflammation-driven degeneration.
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https://jclub.com.au/a/42613369
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A feed-forward UHRF1 read-write mechanism supports H3 multi- mono-ubiquitination and DNA methylation maintenance at CpG-sparse regions
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.25.754493
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ALKBH5-Dependent m(6)A Demethylation Promotes Cardiac Aging Through SLC38A3 Reduction and Glutamine Metabolic Alteration.
Circulation · 22 Sept 2026 · Journal Article
ALKBH5-driven m(6)A demethylation accelerates cardiac aging by decreasing SLC38A3 and disrupting glutamine metabolism, with knockdown delaying aging effects in mice.
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https://jclub.com.au/a/42770216
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PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development.
eLife · 22 Sept 2026 · Journal Article
PRMT1-SFPQ pathway controls intron retention to regulate matrix gene expression during craniofacial development, impacting tissue-specific splicing in CNCCs.
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https://jclub.com.au/a/42770556
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WITHDRAWN: Understanding the molecular activity of Gibbilimbol B on human breast cancer cells
bioRxiv · 18 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.04.674360
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A systematic interactome of Saccharomyces cerevisiae SET1C expands its functional landscape and identifies candidate regulatory connections.
eLife · 16 Sept 2026 · Journal Article
Set1 interacts with over 100 proteins, expanding its known roles to include chromatin regulation, RNA processing, and nuclear-cytoplasmic transport in Saccharomyces cerevisiae.
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https://jclub.com.au/a/42747427
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The expressions and m(6)A methylation modification patterns of mRNAs and lncRNAs in major depressive disorder.
Frontiers in Genetics · 11 Sept 2026 · Journal Article
Altered m(6)A methylation patterns in mRNAs and lncRNAs are significantly associated with major depressive disorder, affecting over 600 RNAs in patient blood samples.
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Recurrent mechanisms of biallelic epigenetic inactivation reveal new putative tumour suppressor genes in prostate cancer.
Nature Communications · 9 Sept 2026 · Journal Article
Biallelic epigenetic inactivation of ZFHX3 occurs at a recurrence rate comparable to TP53 in prostate cancer, promoting oncogene upregulation and metastasis.
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Structural basis of DNA N6-adenine methylation in eukaryotes
bioRxiv · 8 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.08.663716
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Human m(6)A demethylase FTO modulates the flowering time of tomato plants under low-temperature stress.
Plant Physiology and Biochemistry · 1 Sept 2026 · Journal Article
Human FTO acts as an m6A demethylase in tomato, accelerating flowering by up to 50% under low-temperature stress conditions.
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https://jclub.com.au/a/42748505
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TNG961 Is a Selective Oral HBS1L Molecular Glue Degrader for the Treatment of FOCAD-Deleted Cancers.
Cancer Discovery · 1 Sept 2026 · Journal Article
TNG961 is a potent, selective oral degrader of HBS1L that effectively treats FOCAD-deleted cancers, including PRMT5 inhibitor-refractory models.
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https://jclub.com.au/a/42001523
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