Fungal diversity is significantly lower in the gut of glioblastoma patients compared to healthy controls, with a p-value less than 0.001.
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Fungal diversity is significantly lower in the gut of glioblastoma patients compared to healthy controls, with a p-value less than 0.001.
CAR-engineered microglia selectively eliminate GBM cells through phagocytosis in organoid models, showing increased phagocytic activity and tumor transcript internalization.
Targeting cystine/cysteine metabolism with cyst(e)inase reduces lung metastasis in MYC-driven breast cancer models by exploiting a metabolic vulnerability of metastatic cells.
Obesity and aging increase tissue-resident Akkermansia muciniphila in breast tissue, promoting tumorigenesis and oxidative stress in postmenopausal women.
Novel in vivo delivery systems and immune-silent mRNA formulations are advancing mRNA therapeutics 2.0, enabling repeated administration and targeted organ delivery.
Recent advances in microbial engineering have significantly improved the biosynthesis of SAM and its derivatives, with key strategies enhancing production of compounds like ferulic acid and ergothioneine.
Re-examining the temperate phage life cycle reveals unanticipated complexities and emphasizes the importance of viewing properties of (pro)phages as integral to their overall cycle.
Corynebacterium glutamicum and Escherichia coli have achieved maximum L-arginine titers of 92.5 g/L and 132 g/L, respectively, in microbial production systems.
Metastasis-associated migrasomes are enriched in tumor antigens and promote CD8+ T cell responses that constrain metastatic progression.
Mitoribosomal synthetic lethality is a vulnerability in MYC(N)-amplified neuroblastoma, with MYC activation sensitizing cells to mitochondrial ribosome inhibitors.
Intravenous VCN-01 combined with gemcitabine and nab-paclitaxel improves overall survival in metastatic pancreatic ductal adenocarcinoma, with median OS reaching 10.8 months in the FAS population.
Engineered OMV vaccine with nano-encapsulation prevents T cell exhaustion and reduces bacterial burden in chronic bacterial infections.
An iron-dependent methionine redox pathway is essential for adipose browning and influences cachexia progression in mouse models.
Tumor-associated macrophages (TAMs) are the main nonmalignant cells accumulating albumin in tumors, with FcRn-mediated uptake crucial for their maturation and immunotherapy response.
Multi-omics and AI technologies can systematically uncover complex cancer microbiome patterns and associations, advancing understanding and potential clinical applications.
Prophage-encoding engineered E. coli provide prophylactic protection against Salmonella enterica Typhimurium infection in mice by producing high levels of lytic phage before infection.
Plasmids and extrachromosomal DNA share key evolutionary capacities, acting as contingency loci that enable rapid adaptation across bacteria and cancer cells.
Macrophages transfer intact cancer cell surface proteins to their surface during live-cell uptake, significantly altering their proteome without transcriptional changes.
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