Intracellular multienzyme cascade catalysis enhances bioconversion efficiency for non-grain carbon feedstocks by overcoming key limitations in biomanufacturing systems.
Biotechnology advances
Elsevier BV · Microbiology & Mycology · ISSN 0734-9750, 1873-1899
- Impact (2-yr)
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- 301
- Open access
- 5%
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Termite-microbiome symbiosis demonstrates an efficient natural system for lignocellulose deconstruction, enabling rapid biomass conversion under mild conditions.
A systematic Design-Build-Control framework enables precise engineering of bacterial vaccine vectors, addressing safety, immunogenicity, and delivery challenges across multiple platforms.
Nannochloropsis has advanced from basic transformability to achieving biologically and process-relevant levels of native and non-native products, demonstrating its potential as a marine biomanufacturing chassis.
Alternative splicing shows kingdom-specific patterns but is shaped by biological and sampling differences, with conservation and regulation supporting functional and evolutionary insights.
CRISPR-Cas9-mediated multiplex genome editing enhances pathway optimization in electrogenic microbes for bioelectrochemical hydrogen production.
AI-driven aptamer design methods from sequence to function have advanced rapidly between 2024 and 2026, enabling de novo generation and optimization of aptamers.
Plant base editing has expanded from cytosine and adenine editors to include dual-base, transversion, Cas12-based, and organelle-targeted systems, broadening mutation options.
Engineering bacterial outer membrane vesicles enhances their potential as modular, programmable platforms for biotechnological applications.
Black soldier fly larvae (BSFL) lipids, rich in saturated fatty acids like lauric acid, show high potential for sustainable aviation fuel production via HEFA pathways.
Microbial platforms have been engineered to produce tryptophan-derived neuroactive compounds, with recent advances enabling efficient biosynthesis of these therapeutics.
Programmable microalgae with engineered sense-decide-adapt systems can expand their environmental performance envelope under realistic conditions.
Mutagenesis, biosensing, high-throughput screening, and computational approaches collectively advance directed evolution for developing tailored biomolecules across various fields.
Integrative systems biology approaches enable rational engineering of fungal-microbial consortia for ecosystem and industrial applications.
Genome-scale metabolic models (GEMs) guide strain engineering and process optimization, improving fermentation performance across microbial hosts and production contexts.
Advances in microbial ecology and process engineering are transforming anaerobic digestion into a modular biomanufacturing platform capable of producing high-value compounds beyond biogas.
Wild-type and engineered microorganisms can catalyze highly selective diterminal oxidation of n-alkanes into valuable diols and diacids, with enzymatic systems varying by substrate chain length.
Programmable methylation engineering enables robust alkaloid biosynthesis through four key design principles across enzyme, cofactor, and system levels.
Distinct lignocellulosic and cellulose-derived carrier classes are analyzed for biofilm-based food fermentations, emphasizing their structural, functional, and validation differences.
- Open access
Artificial carbohydrate synthesis approaches may surpass photosynthesis by overcoming its fundamental limitations, with potential to revolutionize sustainable carbon fixation.
Synthetic microbiomes enable unprecedented control over nanoparticle size and stability, enhancing robustness and selectivity in environmental nanomanufacturing.
Integrating enzymatic DNA synthesis, assembly, and MutS-based error correction into a continuous pipeline enhances gene construction fidelity and scalability.
- Open access
CAR-T cell therapy and cancer nanovaccines are emerging as powerful, potentially complementary immunotherapy strategies with distinct strengths and limitations across studies.
- Open access
Corynebacterium glutamicum and Escherichia coli have achieved maximum L-arginine titers of 92.5 g/L and 132 g/L, respectively, in microbial production systems.
- 2 cites
Microbial biosynthesis of mevalonate can significantly enhance sustainability and cost-effectiveness compared to conventional chemical synthesis methods.
Expansins and expansin-like proteins are diverse cell wall-loosening proteins present across multiple organisms, with recent discoveries revealing catalytic activity in some ESPs.
- Open access
- 2 cites
Enhancing P450 enzyme components with greater degrees of freedom is key to expanding biocatalytic opportunities in pharmaceutical applications.
- Open access
Geobacter spp. can perform extracellular electron uptake from solid donors, leading to metal corrosion and enabling biotechnological applications.
Genetic code expansion enables multiplex noncanonical amino acid incorporation through codon compression and novel codon creation, expanding protein engineering capabilities.
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Topics moving, week to 22 Oct 2026
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- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
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- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
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