A phased assembly of Harpagifer antarcticus reveals lineage-specific genomic gains and transposon activity linked to cold adaptation in Antarctic notothenioids.
Genome Biology
BioMed Central · Genomics & Bioinformatics · ISSN 1465-6906
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A curated genome-scale nucleotide diversity panel of 3,240 non-human primates from 269 species and 71 genera was created using a ploidy-aware variant calling approach.
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Dicast, a machine learning method, detects structural variants from short-read sequencing data with 20% more candidate pathogenic deletions than consensus approaches.
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Multi-omics and AI technologies can systematically uncover complex cancer microbiome patterns and associations, advancing understanding and potential clinical applications.
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Genolator, a multimodal large language model, achieves high accuracy in answering protein function queries, outperforming GPT 4.1 and smaller domain-specific models.
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Ancient inland southwestern Finland shows nearly a millennium of population continuity, while the coastal zone experienced a significant genetic shift since the Early Medieval period.
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COSIGT accurately genotypes complex loci from low-coverage sequencing, outperforming existing tools at 1-2X coverage and enabling population-scale analysis.
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Bakta outperforms other tools in annotating high-quality bacterial genomes, while PGAP is more effective for archaeal and challenging bacterial assemblies, including metagenome-assembled genomes.
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Genes linked to human polygenic traits show significantly higher connectivity in protein-protein interaction networks, with 4,756 phenotypes analyzed revealing key patterns.
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